Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy

被引:28
作者
Goulart, Luiz Ricardo
Ferreira, Frederico Rogerio
Goulart, Isabela Maria Bernardes
机构
[1] Univ Fed Uberlandia, Inst Genet & Biochem, Genet Mol Lab, BR-38400902 Uberlandia, MG, Brazil
[2] Univ Fed Uberlandia, Natl Reference Ctr Leprosy, BR-38400902 Uberlandia, MG, Brazil
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2006年 / 48卷 / 01期
关键词
leprosy susceptibility; Mitsuda test; VDR gene;
D O I
10.1111/j.1574-695X.2006.00128.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Controversies over the vitamin D receptor (VDR) acting as a susceptibility factor in Mycobacterium sp. infections may be the result of incorrect population stratification. The risk of leprosy occurrence conditioned by VDR polymorphism was investigated by stratifying the population of a highly endemic Brazilian region into negative and positive Mitsuda responses. Leprosy patients (102) and a group of healthy nonconsanguineous household contacts (68) were genotyped for the VDR TaqI polymorphism (T/t). TT and Tt genotypes were not considered to be risk factors as their odds ratios (OR) were not different from those presented by the negative Mitsuda response individuals. The combination of the tt genotype and the negative Mitsuda test provided an occurrence rate 13 times higher in leprosy patients than in controls with positive Mitsuda responses. This suggests that there is a higher risk of leprosy development when individuals carry this unfavorable combination, and demonstrates a possible synergistic role of these two variables in leprosy susceptibility via effects on cellular immunity.
引用
收藏
页码:91 / 98
页数:8
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