A gold(I) complex with a vitamin K3 derivative:: Characterization and antitumoral activity

被引：55

作者：

Casas, Jose S. ^{[1
]}

Castellano, Eduardo E.

Couce, Maria D.

Ellena, Javier

Sanchez, Agustin

Sordo, Jose

Taboada, Carmen

机构：

[1] Univ Santiago de Compostela, Fac Farm, Dept Quim Inorgan, Santiago De Compostela 15782, Galicia, Spain

[2] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560 Sao Carlos, SP, Brazil

[3] Univ Vigo, Fac Ciencias, Dept Quim Inorgan, Vigo 36200, Spain

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2006年 / 100卷 / 11期

关键词：

gold(I) complex; vitamin K-3; X-ray structure; antitumoral activity;

D O I：

10.1016/j.jinorgbio.2006.07.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Reaction of the vitamin K-3 derivative menadione sodium bisulfite thiosemicarbazone (NaK3TSC) with chloro(triethylphosphine)gold(I) afforded the complex [AuPEt3(K3TSC)]. This compound consists of discrete molecules in which the metal is almost linearly coordinated to P and S. Preliminary in vitro screening showed significant anti-cancer activity, notably against the cisplatin-resistant cell line A2780cis. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1858 / 1860

页数：3

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