Preimplantation-embryo-specific cell cycle regulation is attributed to the low expression level of retinoblastoma protein

被引：22

作者：

Iwamori, N ^{[1
]}

Naito, K ^{[1
]}

Sugiura, K ^{[1
]}

Tojo, H ^{[1
]}

机构：

[1] Univ Tokyo, Lab Appl Genet, Dept Anim Resource Sci, Grad Sch Agr & Life Sci,Bunkyo Ku, Tokyo 1138657, Japan

来源：

FEBS LETTERS | 2002年 / 526卷 / 1-3期

基金：

日本学术振兴会;

关键词：

RB; preimplantation embryo; cell cycle; microinjection;

D O I：

10.1016/S0014-5793(02)03121-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It is known that a characteristic of the mammalian preimplantation-embryo-specific cell cycle is the substantially shortened G1-phase, although the regulation mechanisms of the unique cell cycle remain unclear. In the present study, we first examined the presence of retinoblastoma (RB) tumor suppressor gene product throughout mouse preimplantation embryo development and found that the RB expression was down-regulated between the four-cell and morula stages. Furthermore, the overexpression of RB protein in the mouse embryos during this phase inhibited their development significantly. These results suggest that the absence of RB protein contributes to the preimplantation-embryo-specific cell cycle. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：119 / 123

页数：5

共 36 条

[1] CYCLIN D1 IS A NUCLEAR-PROTEIN REQUIRED FOR CELL-CYCLE PROGRESSION IN G(1) [J].