Inhibition of prion-protein conversion: a therapeutic tool?

被引:20
作者
Head, MW [1 ]
Ironside, JW [1 ]
机构
[1] Univ Edinburgh, Western Gen Hosp, CJD Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland
关键词
D O I
10.1016/S0966-842X(99)01656-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:6 / 8
页数:3
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共 20 条
[1]   MS-8209, a water-soluble amphotericin B derivative, affects both scrapie agent replication and PrPres accumulation in Syrian hamster scrapie [J].
Adjou, KT ;
Demaimay, R ;
Deslys, JP ;
Lasmézas, CI ;
Beringue, V ;
Demart, S ;
Lamoury, F ;
Seman, M ;
Dormont, D .
JOURNAL OF GENERAL VIROLOGY, 1999, 80 :1079-1085
[2]   NONGENETIC PROPAGATION OF STRAIN-SPECIFIC PROPERTIES OF SCRAPIE PRION PROTEIN [J].
BESSEN, RA ;
KOCISKO, DA ;
RAYMOND, GJ ;
NANDAN, S ;
LANSBURY, PT ;
CAUGHEY, B .
NATURE, 1995, 375 (6533) :698-700
[3]   Specific inhibition of in vitro formation of protease-resistant prion protein by synthetic peptides [J].
Chabry, J ;
Caughey, B ;
Chesebro, B .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (21) :13203-13207
[4]   Species-independent inhibition of abnormal prion protein (PrP) formation by a peptide containing a conserved PrP sequence [J].
Chabry, J ;
Priola, SA ;
Wehrly, K ;
Nishio, J ;
Hope, J ;
Chesebro, B .
JOURNAL OF VIROLOGY, 1999, 73 (08) :6245-6250
[5]   Chaperone-supervised conversion of prion protein to its protease-resistant form [J].
DebBurman, SK ;
Raymond, GJ ;
Caughey, B ;
Lindquist, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13938-13943
[6]   Prophylactic potential of pentosan polysulphate in transmissible spongiform encephalopathies [J].
Farquhar, C ;
Dickinson, A ;
Bruce, M .
LANCET, 1999, 353 (9147) :117-117
[7]   PROLONGATION OF SCRAPIE INCUBATION PERIOD BY AN INJECTION OF DEXTRAN SULFATE 500 WITHIN THE MONTH BEFORE OR AFTER INFECTION [J].
FARQUHAR, CF ;
DICKINSON, AG .
JOURNAL OF GENERAL VIROLOGY, 1986, 67 :463-473
[8]   Scrapie-induced neuron loss is reduced by treatment with basic fibroblast growth factor [J].
Fraser, JR ;
Brown, J ;
Bruce, ME ;
Jeffrey, M .
NEUROREPORT, 1997, 8 (9-10) :2405-2409
[9]   Specific binding of normal prion protein to the scrapie form via a localized domain initiates its conversion to the protease-resistant state [J].
Horiuchi, M ;
Caughey, B .
EMBO JOURNAL, 1999, 18 (12) :3193-3203
[10]   CONGO RED PROLONGS THE INCUBATION PERIOD IN SCRAPIE-INFECTED HAMSTERS [J].
INGROSSO, L ;
LADOGANA, A ;
POCCHIARI, M .
JOURNAL OF VIROLOGY, 1995, 69 (01) :506-508