Borrelia burgdorferi induces inflammatory mediator production by murine microglia

被引：64

作者：

Rasley, A ^{[1
]}

Anguita, J ^{[1
]}

Marriott, I ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Charlotte, NC 28223 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2002年 / 130卷 / 1-2期

关键词：

Lyme neuroborreliosis; microglia; inflammation; Toll-like receptors;

D O I：

10.1016/S0165-5728(02)00187-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lyme disease has been associated with damaging inflammation within the central nervous system. In the present study, we demonstrate that Borrelia burgdorferi is a significant stimulus for the production of IL-6, TNF-alpha, and PGE(2) by microglia. This effect is associated with induction of NF-kappaB, and increased expression of Toll-like receptor 2 and CD14, receptors known to underlie spirochete activation of other immune cell types. These studies identify microglia as a previously unappreciated source of inflammatory mediator production following challenge with B. burgdorferi. Such production may play an important role during the development of Lyme neuroborreliosis. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：22 / 31

页数：10

共 53 条

[1]

Aloisi F, 1999, J NEUROSCI RES, V56, P571

[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].