An Efficient Four-Component Approach for the Synthesis of Novel 5-Methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)-1-arylethyl)-1H-pyrazol-3-ol Derivatives and their Antibacterial Study

被引：15
|
作者：
Muthineni, Narmada [1 ]
Kumar, Nandigama Satish [1 ]
Rao, L. Chandrasekhara [1 ]
Kumar, V. Dileep [2 ]
Misra, Sunil [2 ]
Chowhan, L. Raju [3 ]
Meshram, H. M. [1 ]
机构：
[1] Indian Inst Chem Technol, CSIR, Med Chem & Pharmacol Div, Hyderabad 500007, Andhra Pradesh, India
[2] Indian Inst Chem Technol, CSIR, Div Biol, Hyderabad 500007, Andhra Pradesh, India
[3] Cent Univ Gujarat, Sch Chem Sci, Gandhinagar 38203, India
来源：
CHEMISTRYSELECT | 2016年 / 1卷 / 14期
关键词：
Anti-bacterial; 3; 5-dimethyl-4-nitroisoxazole; Efficient; Multi-component reactions (MCRs); Pyrazolone; MULTICOMPONENT SYNTHESIS; AQUEOUS-MEDIA; CATALYST-FREE; ONE-POT; INHIBITORS; WATER; 2H-CHROMENES; CHEMISTRY; DESIGN;
D O I：
10.1002/slct.201600915
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A One pot four-component domino reactions were developed for the synthesis of 5-methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)- 1-arylethyl)-1H-pyrazol-3-ols derivatives in excellent yield from hydrazine hydrate (1), ethyl acetoacetate (2), aldehyde (3) and 3,5-dimethyl-4-nitro-isoxazole (4) using 10 mol% of piperidine. This method is simple, efficient and multiple bonds were generated (two C = C, one C = N, one O = H and one C = N) in a single step. These novel 5-methyl-4-(2-(3-methyl-4-nitroisoxazol-5-yl)- 1-arylethyl)-1H-pyrazol-3-ol derivatives are evaluated as antibacterial agents.
引用
收藏
页码：4197 / 4202
页数：6
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