Synthesis of 3-beta-D-ribofuranosyl-1H-pyrazole-4-carboxamide

被引：10

作者：

Nishiyama, Y ^{[1
]}

Nishimura, N ^{[1
]}

Kuroyanagi, N ^{[1
]}

Maeba, I ^{[1
]}

机构：

[1] MEIJO UNIV,FAC PHARM,TEMPAKU KU,NAGOYA,AICHI 468,JAPAN

来源：

CARBOHYDRATE RESEARCH | 1997年 / 300卷 / 03期

关键词：

synthesis; C-nucleoside; pyrazole-4-carboxamide; glycosyl enaminone;

D O I：

10.1016/S0008-6215(97)00047-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 3-beta-D-ribofuranosyl-1H-pyrazole-4-carboxamide (11) is described. Treatment of enaminone glycoside 1 with trimethyl orthoformate afforded the aldehyde 2. The aldehyde 2 was oximated with hydroxylamine. Grime 3 was cyclized with hydrazine to afford the pyrazole 8. The pyrazole 8 was dehydrated with acetic anhydride, and the nitrile 9 was treated with nickel acetate in acetic acid. The resulting carboxamide 10 was deblocked by aq ammonia gave 11. (C) 1997 Published by Elsevier Science Ltd.

引用

页码：283 / 288

页数：6

共 9 条

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