Prediction of clinical outcome after stereotactic body radiotherapy for non-small cell lung cancer using diffusion-weighted MRI and 18F-FDG PET

Purpose/objectives: To evaluate the use of diffusion-weighted magnetic resonance imaging (DW-MRI) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for predicting disease progression (DP) among patients with non-small cell lung carcinoma (NSCLC) treated with stereotactic body radiotherapy (SBRT). Materials/methods: Fifteen patients with histologically confirmed stage I NSCLC who underwent pretreatment DW-MRI and PET and were treated with SBRT were enrolled. The mean apparent diffusion coefficient (ADC) value and maximum standardised uptake value (SUVmax) were measured at the target lesion and evaluated for correlations with DP. Results: The median pre-treatment ADC value was 1.04 x 10(-3) (range 0.83-1.29 x 10(-3)) mm(2)/s, and the median pre-treatment SUVmax was 9.9 (range 1.6-30). There was no correlation between the ADC value and SUV,T,a. The group with the lower ADC value (<= 1.05 x 10(-3) mm(2)/s) and that with a higher SUVmax (>= 7.9) tended to have poor DP, but neither trend was statistically significant (p = 0.09 and 0.32, respectively). The combination of the ADC value and SUVmax was a statistically significant predictor of DP (p = 0.036). Conclusion: A low ADC value on pre-treatment DW-MRI and a high SUV,Tiax may be associated with poor DP in NSCLC patients treated with SBRT. Using both values in combination was a better predictor. (C) 2014 Elsevier Ireland Ltd. All rights reserved.