Detrimental impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and immune Homeostasis: An Overview

被引：106
作者：
Daien, Claire Immediato [1 ,2 ,3 ]
Pinget, Gabriela Veronica [1 ,2 ]
Tan, Jian Kai [4 ]
Macia, Laurence [1 ,2 ,4 ]
机构：
[1] Univ Sydney, Charles Perkins Ctr, Nutr Immunometab Node Lab, Sydney, NSW, Australia
[2] Univ Sydney, Sch Med Sci, Sydney, NSW, Australia
[3] Montpellier Univ, UMR5535, Inst Genet Mol Montpellier, Montpellier, France
[4] Monash Univ, Monash Biomed Discovery Inst, Dept Biochem & Mol Biol, Infect & Immun Program, Clayton, Vic, Australia
来源：
FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
dietary fiber; microbiota-accessible carbohydrates; immunity; gut homeostasis; gut barrier; gut microbiota; epithelium; CHAIN FATTY-ACIDS; INTESTINAL EPITHELIAL-CELLS; REGULATORY T-CELLS; INFLAMMATORY DISEASES; GOBLET CELLS; METABOLITES; FIBER; ASTHMA; HEALTH; EXPRESSION;
D O I：
10.3389/fimmu.2017.00548
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dietary fibers are non-digestible polysaccharides functionally known as microbiota-accessible carbohydrates (MACs), present in inadequate amounts in the Western diet. MACs are a main source of energy for gut bacteria so the abundance and variety of MACs can modulate gut microbial composition and function. This, in turn, impacts host immunity and health. In preclinical studies, MAC-deprived diet and disruption of gut homeostasis aggravate the development of inflammatory diseases, such as allergies, infections, and autoimmune diseases. The present review provides a synopsis on the impact of a low-MAC diet on gut homeostasis or, more specifically, on gut microbiota, gut epithelium, and immune cells.
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页数：7
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