Detrimental impact of Microbiota-Accessible Carbohydrate-Deprived Diet on Gut and immune Homeostasis: An Overview

被引：106

作者：

Daien, Claire Immediato ^{[1
,2
,3
]}

Pinget, Gabriela Veronica ^{[1
,2
]}

Tan, Jian Kai ^{[4
]}

Macia, Laurence ^{[1
,2
,4
]}

机构：

[1] Univ Sydney, Charles Perkins Ctr, Nutr Immunometab Node Lab, Sydney, NSW, Australia

[2] Univ Sydney, Sch Med Sci, Sydney, NSW, Australia

[3] Montpellier Univ, UMR5535, Inst Genet Mol Montpellier, Montpellier, France

[4] Monash Univ, Monash Biomed Discovery Inst, Dept Biochem & Mol Biol, Infect & Immun Program, Clayton, Vic, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2017年 / 8卷

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

dietary fiber; microbiota-accessible carbohydrates; immunity; gut homeostasis; gut barrier; gut microbiota; epithelium; CHAIN FATTY-ACIDS; INTESTINAL EPITHELIAL-CELLS; REGULATORY T-CELLS; INFLAMMATORY DISEASES; GOBLET CELLS; METABOLITES; FIBER; ASTHMA; HEALTH; EXPRESSION;

D O I：

10.3389/fimmu.2017.00548

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dietary fibers are non-digestible polysaccharides functionally known as microbiota-accessible carbohydrates (MACs), present in inadequate amounts in the Western diet. MACs are a main source of energy for gut bacteria so the abundance and variety of MACs can modulate gut microbial composition and function. This, in turn, impacts host immunity and health. In preclinical studies, MAC-deprived diet and disruption of gut homeostasis aggravate the development of inflammatory diseases, such as allergies, infections, and autoimmune diseases. The present review provides a synopsis on the impact of a low-MAC diet on gut homeostasis or, more specifically, on gut microbiota, gut epithelium, and immune cells.

引用

页数：7

共 52 条

[1] INCREASE OF ASTHMA, ALLERGIC RHINITIS AND ECZEMA IN SWEDISH SCHOOLCHILDREN BETWEEN 1979 AND 1991 [J].

ABERG, N ;

HESSELMAR, B ;

ABERG, B ;

ERIKSSON, B .

CLINICAL AND EXPERIMENTAL ALLERGY, 1995, 25 (09) :815-819

[2] Low gut microbiota diversity in early infancy precedes asthma at school age [J].

Abrahamsson, T. R. ;

Jakobsson, H. E. ;

Andersson, A. F. ;

Bjorksten, B. ;

Engstrand, L. ;

Jenmalm, M. C. .

CLINICAL AND EXPERIMENTAL ALLERGY, 2014, 44 (06) :842-850

[3] Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation [J].

Arpaia, Nicholas ;

Campbell, Clarissa ;

Fan, Xiying ;

Dikiy, Stanislav ;

van der Veeken, Joris ;

deRoos, Paul ;

Liu, Hui ;

Cross, Justin R. ;

Pfeffer, Klaus ;

Coffer, Paul J. ;

Rudensky, Alexander Y. .

NATURE, 2013, 504 (7480) :451-+

[4] Modulation of intestinal goblet cell function during infection by an attaching and effacing bacterial pathogen [J].

Bergstrom, Kirk S. B. ;

Guttman, Julian A. ;

Rumi, Mohammad ;

Ma, Caixia ;

Bouzari, Saied ;

Khan, Mohammed A. ;

Gibson, Deanna L. ;

Vogl, A. Wayne ;

Vallance, Bruce A. .

INFECTION AND IMMUNITY, 2008, 76 (02) :796-811

[5] Origins and evolution of the Western diet: health implications for the 21st century [J].

Cordain, L ;

Eaton, SB ;

Sebastian, A ;

Mann, N ;

Lindeberg, S ;

Watkins, BA ;

O'Keefe, JH ;

Brand-Miller, J .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 81 (02) :341-354

[6] Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa [J].

De Filippo, Carlotta ;

Cavalieri, Duccio ;

Di Paola, Monica ;

Ramazzotti, Matteo ;

Poullet, Jean Baptiste ;

Massart, Sebastien ;

Collini, Silvia ;

Pieraccini, Giuseppe ;

Lionetti, Paolo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (33) :14691-14696

[7] A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility [J].

Desai, Mahesh S. ;

Seekatz, Anna M. ;

Koropatkin, Nicole M. ;

Kamada, Nobuhiko ;

Hickey, Christina A. ;

Wolter, Mathis ;

Pudlo, Nicholas A. ;

Kitamoto, Sho ;

Terrapon, Nicolas ;

Muller, Arnaud ;

Young, Vincent B. ;

Henrissat, Bernard ;

Wilmes, Paul ;

Stappenbeck, Thaddeus S. ;

Nunez, Gabriel ;

Martens, Eric C. .

CELL, 2016, 167 (05) :1339-+

[8] The abundance and variety of carbohydrate-active enzymes in the human gut microbiota [J].

El Kaoutari, Abdessamad ;

Armougom, Fabrice ;

Gordon, Jeffrey I. ;

Raoult, Didier ;

Henrissat, Bernard .

NATURE REVIEWS MICROBIOLOGY, 2013, 11 (07) :497-504

[9] Bifidobacteria can protect from enteropathogenic infection through production of acetate [J].

Fukuda, Shinji ;

Toh, Hidehiro ;

Hase, Koji ;

Oshima, Kenshiro ;

Nakanishi, Yumiko ;

Yoshimura, Kazutoshi ;

Tobe, Toru ;

Clarke, Julie M. ;

Topping, David L. ;

Suzuki, Tohru ;

Taylor, Todd D. ;

Itoh, Kikuji ;

Kikuchi, Jun ;

Morita, Hidetoshi ;

Hattori, Masahira ;

Ohno, Hiroshi .

NATURE, 2011, 469 (7331) :543-U791

[10] Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells [J].

Furusawa, Yukihiro ;

Obata, Yuuki ;

Fukuda, Shinji ;

Endo, Takaho A. ;

Nakato, Gaku ;

Takahashi, Daisuke ;

Nakanishi, Yumiko ;

Uetake, Chikako ;

Kato, Keiko ;

Kato, Tamotsu ;

Takahashi, Masumi ;

Fukuda, Noriko N. ;

Murakami, Shinnosuke ;

Miyauchi, Eiji ;

Hino, Shingo ;

Atarashi, Koji ;

Onawa, Satoshi ;

Fujimura, Yumiko ;

Lockett, Trevor ;

Clarke, Julie M. ;

Topping, David L. ;

Tomita, Masaru ;

Hori, Shohei ;

Ohara, Osamu ;

Morita, Tatsuya ;

Koseki, Haruhiko ;

Kikuchi, Jun ;

Honda, Kenya ;

Hase, Koji ;

Ohno, Hiroshi .

NATURE, 2013, 504 (7480) :446-+

← 1 2 3 4 5 6 →