Novel polymorphisms of the KCNB1 gene and their association with production traits in Indian Sahiwal cattle

被引:1
作者
Kumari, Ragini [1 ,2 ]
Kumar, Rakesh [1 ,3 ]
Sinha, Beena [1 ,4 ]
Sinha, Rebeka [1 ,5 ]
Gupta, Ishwar Dayal [1 ,6 ]
Verma, Archana [1 ,6 ]
机构
[1] ICAR Natl Dairy Res Inst, Karnal 132001, Haryana, India
[2] Chhapra, Saran, Bihar, India
[3] ICAR Res Complex Eastern Reg, Patna, Bihar, India
[4] Kusherhi, Sheikhpura, Bihar, India
[5] Guru Angad Dev Vet & Anim Sci Univ, Coll Vet Sci, Ludhiana, Punjab, India
[6] ICAR Natl Dairy Res Inst, Karnal, Haryana, India
关键词
Cattle; KCNB1; Mastitis; Polymorphism; Production; Sahiwal; SOMATIC-CELL SCORE; UDDER TYPE TRAITS; CLINICAL MASTITIS; TEAT; PARAMETERS; RESISTANCE; COUNT;
D O I
10.56093/ijans.v92i12.117454
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
Mastitis in cattle is a prevalent mammary gland disease that contributes significantly to the increase in veterinary expenditures in the dairy sector. KCNB1 (Potassium voltage-gated channel, subfamily B member 1) gene is involved in regulating apoptosis, cell proliferation and differentiation, udder epithelial tissue maintenance and repair, mammary gland development and recommended as a candidate gene for production related traits in cattle. The purpose of this research was to detect the genetic variants of KCNB1 gene in Sahiwal cattle and to analyze the association between polymorphisms with milk production traits, udder traits, and teat traits in Sahiwal cattle. A total of 87 cattle were genotyped by polymerase chain reaction-restriction fragment length polymorphism technique. Two single nucleotide polymorphisms within the non-coding sequence of KCNB1 gene were identified (g.78216220G>A and g.78216335A>G). Analysis of productivity traits within the genotyped animals revealed that the SNP1-Msp1 locus (g.78216220G>A) located at intron 1 was associated with milk production traits, but the SNP2-BspHI locus (g.78216335A>G) had no association with milk production. Significant associations were also observed between SNP1-Msp1 and SNP2-BspHI loci with both udder and teat traits. Our results demonstrate that polymorphisms in the cattle KCNB1 gene were associated with milk production, udder and teat traits and might be utilized as a genetic marker for marker-assisted selection in cattle breeding programs.
引用
收藏
页码:1422 / 1428
页数:7
相关论文
共 39 条
  • [1] Asaf VNM, 2015, INDIAN J ANIM SCI, V85, P81
  • [2] Atkins G, 2002, ADV DAIRY TECHNOL, V14, P93
  • [3] Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary US Holstein cows
    Cole, John B.
    Wiggans, George R.
    Ma, Li
    Sonstegard, Tad S.
    Lawlor, Thomas J., Jr.
    Crooker, Brian A.
    Van Tassell, Curtis P.
    Yang, Jing
    Wang, Shengwen
    Matukumalli, Lakshmi K.
    Da, Yang
    [J]. BMC GENOMICS, 2011, 12
  • [4] A SIMULATION STUDY OF SELECTION METHODS TO IMPROVE MASTITIS RESISTANCE OF DAIRY-COWS
    COLLEAU, JJ
    LEBIHANDUVAL, E
    [J]. JOURNAL OF DAIRY SCIENCE, 1995, 78 (03) : 659 - 671
  • [5] Daldaban Fadime, 2021, Harran Universitesi Veteriner Fakultesi Dergisi, V10, P12, DOI 10.31196/huvfd.806050
  • [6] Genetic parameters of pathogen-specific incidence of clinical mastitis in dairy cows
    de Haas, Y
    Barkema, HW
    Veerkamp, RF
    [J]. ANIMAL SCIENCE, 2002, 74 : 233 - 242
  • [7] Gene Architecture Facilitates Intron-Mediated Enhancement of Transcription
    Dwyer, Katherine
    Agarwal, Neha
    Pile, Lori
    Ansari, Athar
    [J]. FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 8
  • [8] HAU, 2016, US
  • [9] Genetic Association of PPARGC1A Gene Single Nucleotide Polymorphism with Milk Production Traits in Italian Mediterranean Buffalo
    Hosseini, Seyed Mahdi
    Ye Tingzhu
    Pasandideh, Majid
    Liang, Aixin
    Hua, Guohua
    Farmanullah
    Schreurs, Nicola M.
    Raza, Sayed Haidar Abbas
    Salzano, Angela
    Campanile, Giuseppe
    Gasparrini, Bianca
    Yang, Liguo
    [J]. BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [10] ICAR, 2012, CONF REC DAIR CATTL