Common Genetic Variants Explain the Majority of the Correlation Between Height and Intelligence: The Generation Scotland Study

被引：33

作者：

Marioni, Riccardo E. ^{[1
,2
,3
]}

Batty, G. David ^{[1
,4
,5
]}

Hayward, Caroline ^{[6
]}

Kerr, Shona M. ^{[6
]}

Campbell, Archie ^{[2
]}

Hocking, Lynne J. ^{[7
]}

Scotland, Generation

Porteous, David J. ^{[1
,2
]}

Visscher, Peter M. ^{[1
,3
,8
]}

Deary, Ian J. ^{[1
,9
]}

机构：

[1] Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Genom & Expt Med, Inst Genet & Mol Med, Med Genet Sect, Edinburgh EH4 2XU, Midlothian, Scotland

[3] Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia

[4] UCL, Dept Epidemiol & Publ Hlth, London WC1E 6BT, England

[5] Univ Edinburgh, Alzheimer Scotland Dementia Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland

[6] Univ Edinburgh, Inst Genet & Mol Med, Med Res Council, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[7] Univ Aberdeen, Div Appl Med, Musculoskeletal Res Programme, Aberdeen AB25 2ZD, Scotland

[8] Univ Queensland, Translat Res Inst, Diamantina Inst, Brisbane, Qld 4072, Australia

[9] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland

来源：

BEHAVIOR GENETICS | 2014年 / 44卷 / 02期

基金：

英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

Height; Intelligence; Molecular genetics; Genetic correlation; Generation Scotland; HERITABILITY; ASSOCIATION; PLEIOTROPY; CHILDHOOD; DISEASE; SAMPLES; COHORT; HEALTH;

D O I：

10.1007/s10519-014-9644-z

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Greater height and higher intelligence test scores are predictors of better health outcomes. Here, we used molecular (single-nucleotide polymorphism) data to estimate the genetic correlation between height and general intelligence (g) in 6,815 unrelated subjects (median age 57, IQR 49-63) from the Generation Scotland: Scottish Family Health Study cohort. The phenotypic correlation between height and g was 0.16 (SE 0.01). The genetic correlation between height and g was 0.28 (SE 0.09) with a bivariate heritability estimate of 0.71. Understanding the molecular basis of the correlation between height and intelligence may help explain any shared role in determining health outcomes. This study identified a modest genetic correlation between height and intelligence with the majority of the phenotypic correlation being explained by shared genetic influences.

引用

页码：91 / 96

页数：6

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