Effect of Specific Amino Acids on Controlling Crystal Pseudopolymorphism of L-Arginine Hydrochloride

被引：1

作者：

Shimizu, Takeshi ^{[1
]}

Yoshiura, Hiromu ^{[2
]}

Nagano, Hiroshi ^{[1
]}

Hirasawa, Izumi ^{[3
]}

机构：

[1] Kyowa Hakko Bio Co Ltd, Tech Res Labs, Hofu, Yamaguchi, Japan

[2] BioKyowa Inc, Tech Dept, Cape Girardeau, MO 63702 USA

[3] Waseda Univ, Dept Appl Chem, Grad Sch Adv Sci & Engn, Shinjuku Ku, Tokyo 169, Japan

来源：

CHEMICAL ENGINEERING & TECHNOLOGY | 2014年 / 37卷 / 08期

关键词：

Amino acids; Crystallization; Impurities; Pseudopolymorphism; CRYSTALLIZATION; POLYMORPHISM; GLYCINE;

D O I：

10.1002/ceat.201300695

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The effect of a small amount of amino acid additives on the pseudopolymorphism of L-arginine hydrochloride (LAHCL) in aqueous solution is reported. Results confirm that L-alanine (L-Ala) has a stabilizing effect on the crystals of the anhydrate form of LAHCL at low temperature. Intriguingly, the stabilizing effect was observed even when L-Ala was added after a large amount of LAHCL had formed. In contrast, no stabilizing effect with D-Ala could be stated, suggesting that the stereochemistry of the additives is an important factor. In addition to the stereochemistry, also the length and bulkiness of the alkyl side-chain of the amino acids were found to be significant factors. Based on these results, a mechanism is proposed for stabilization of anhydrate LAHCL crystals by amino acid additives.

引用

页码：1427 / 1430

页数：4

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