Brain Arteriovenous Malformation Modeling, Pathogenesis, and Novel Therapeutic Targets

被引：48
作者：
Chen, Wanqiu [1 ]
Choi, Eun-Jung [1 ]
McDougall, Cameron M. [1 ]
Su, Hua [1 ]
机构：
[1] Univ Calif San Francisco, Ctr Cerebrovasc Res, Dept Anesthesia & Perioperat Care, San Francisco, CA 94110 USA
来源：
TRANSLATIONAL STROKE RESEARCH | 2014年 / 5卷 / 03期
基金：
美国国家卫生研究院;
关键词：
Activin-like kinase 1; Angiogenesis; Brain arteriovenous malformation; Conditional knockout; Endoglin; Hereditary hemorrhagic telangiectasia; Mouse models; HEREDITARY HEMORRHAGIC TELANGIECTASIA; ENDOTHELIAL GROWTH-FACTOR; CAUSE CEREBROVASCULAR DYSPLASIA; HYPOXIA-INDUCIBLE FACTOR; MATRIX METALLOPROTEINASES; MOUSE MODEL; INTRACRANIAL HEMORRHAGE; VASCULAR MALFORMATIONS; ADULT-MOUSE; BONE-MARROW;
D O I：
10.1007/s12975-014-0343-0
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Patients harboring brain arteriovenous malformation (bAVM) are at life-threatening risk of rupture and intracranial hemorrhage (ICH). The pathogenesis of bAVM has not been completely understood. Current treatment options are invasive, and a parts per thousand 20 % of patients are not offered interventional therapy because of excessive treatment risk. There are no specific medical therapies to treat bAVMs. The lack of validated animal models has been an obstacle for testing hypotheses of bAVM pathogenesis and testing new therapies. In this review, we summarize bAVM model development and bAVM pathogenesis and potential therapeutic targets that have been identified during model development.
引用
收藏
页码：316 / 329
页数：14
相关论文
共 172 条
  • [1] Association of tumor necrosis factor-α-238G>A and apolipoprotein E2 polymorphisms with intracranial hemorrhage after brain artericivenous malformation treatment
    Achrol, Achal S.
    Kim, Helen
    Pawlikowska, Ludmila
    Poon, K. Y. Trudy
    McCulloch, Charles E.
    Ko, Nerissa U.
    Johnston, S. Claiborne
    McDermott, Michael W.
    Zaroff, Jonathan G.
    Lawton, Michael T.
    Kwok, Pui-Yan
    Young, William L.
    [J]. NEUROSURGERY, 2007, 61 (04) : 731 - 739
  • [2] Achrol AS, 2006, STROKE, V37, P638
  • [3] Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis
    Akers, Amy L.
    Johnson, Eric
    Steinberg, Gary K.
    Zabramski, Joseph M.
    Marchuk, Douglas A.
    [J]. HUMAN MOLECULAR GENETICS, 2009, 18 (05) : 919 - 930
  • [4] Alam MA, 2011, BMJ CASE REP
  • [5] A Case Report of a Patient with Hereditary Hemorrhagic Telangiectasia Treated Successively with Thalidomide and Bevacizumab
    Amanzada, Ahmad
    Toeppler, Gwen-Jana
    Cameron, Silke
    Schwoerer, Harald
    Ramadori, Giuliano
    [J]. CASE REPORTS IN ONCOLOGY, 2010, 3 (03): : 463 - 470
  • [6] Thalidomide analogues as anticancer drugs
    Aragon-Ching, Jeanny B.
    Li, Haiqing
    Gardner, Erin R.
    Figg, William D.
    [J]. RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY, 2007, 2 (02) : 167 - 174
  • [7] Endoglin, an ancillary TGFβ receptor, is required for extraembryonic angiogenesis and plays a key role in heart development
    Arthur, HM
    Ure, J
    Smith, AJH
    Renforth, G
    Wilson, DI
    Torsney, E
    Charlton, R
    Parums, DV
    Jowett, T
    Marchuk, DA
    Burn, J
    Diamond, AG
    [J]. DEVELOPMENTAL BIOLOGY, 2000, 217 (01) : 42 - 53
  • [8] Prospective, randomized, double-blind trial investigating the effect of doxycycline on matrix metalloproteinase expression within atherosclerotic carotid plaques
    Axisa, B
    Loftus, IM
    Naylor, AR
    Goodall, S
    Jones, L
    Bell, PRF
    Thompson, MM
    [J]. STROKE, 2002, 33 (12) : 2858 - 2864
  • [9] Activation of Nuclear Factor κB in Cerebral Arteriovenous Malformations
    Aziz, Mohamed Mostafa
    Takagi, Yasushi
    Hashimoto, Nobuo
    Miyamoto, Susumu
    [J]. NEUROSURGERY, 2010, 67 (06) : 1669 - 1679
  • [10] Preliminary Results of the ARUBA Study
    Bambakidis, Nicholas C.
    Cockroft, Kevin
    Connolly, E. Sander
    Amin-Hanjani, Sepideh
    Morcos, Jacques
    Meyers, Philip M.
    Alexander, Michael J.
    Friedlander, Robert M.
    [J]. NEUROSURGERY, 2013, 73 (02) : E379 - E381
12345678910