Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography

被引：74

作者：

Wegner, Florian ^{[1
]}

Wilke, Florian ^{[2
]}

Raab, Peter ^{[3
]}

Ben Tayeb, Said ^{[1
]}

Boeck, Anna-Lena ^{[1
]}

Haense, Cathleen ^{[4
]}

Trebst, Corinna ^{[1
]}

Voss, Elke ^{[1
]}

Schrader, Christoph ^{[1
]}

Logemann, Frank ^{[5
]}

Ahrens, Joerg ^{[5
]}

Leffler, Andreas ^{[5
]}

Rodriguez-Raecke, Rea ^{[1
]}

Dengler, Reinhard ^{[1
]}

Geworski, Lilli ^{[2
]}

Bengel, Frank M. ^{[4
]}

Berding, Georg ^{[4
]}

Stangel, Martin ^{[1
]}

Nabavi, Elham ^{[4
]}

机构：

[1] Hannover Med Sch, Dept Neurol, D-30625 Hannover, Germany

[2] Hannover Med Sch, Dept Med Phys, D-30625 Hannover, Germany

[3] Hannover Med Sch, Inst Neuroradiol, D-30625 Hannover, Germany

[4] Hannover Med Sch, Dept Nucl Med, D-30625 Hannover, Germany

[5] Hannover Med Sch, Dept Anesthesia & Crit Care Med, D-30625 Hannover, Germany

来源：

BMC NEUROLOGY | 2014年 / 14卷

关键词：

Anti-leucine rich glioma inactivated 1 protein (LGI1); Anti-N-methyl-D-aspartate (NMDA) receptor antibody; Paraneoplastic syndrome; Autoimmune limbic encephalitis; Brain glucose metabolism; 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET); PARANEOPLASTIC LIMBIC ENCEPHALITIS; PET/CT FINDINGS; PROPOFOL ANESTHESIA; FDG-PET; AUTOANTIBODIES; ANTIBODIES; EPILEPSY; MRI; DISORDER; F-18-FDG;

D O I：

10.1186/1471-2377-14-136

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in F-18-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis. Methods: The brain F-18-fluoro-2-deoxy-d-glucose uptake from whole body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and tour patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls. Results: Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism. Conclusions: This retrospective F-18-fluor-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti N methyl-D-aspartate receptor encephalitis.

引用

页数：11

共 43 条

[11] Improvement of non-paraneoplastic voltage-gated potassium channel antibody-associated limbic encephalitis without immunosuppressive therapy [J].

Gast, Heidemarie ;

Schindler, Kaspar ;

Z'Graggen, Werner J. ;

Hess, Christian W. .

EPILEPSY & BEHAVIOR, 2010, 17 (04) :555-557

[12] Pathogenic and physiological autoantibodies in the central nervous system [J].

Gold, Maike ;

Pul, Refik ;

Bach, Jan-Philipp ;

Stangel, Martin ;

Dodel, Richard .

IMMUNOLOGICAL REVIEWS, 2012, 248 :68-86

[13]

Graus F, 2004, J NEUROL NEUROSUR PS, V75, P1135, DOI 10.1136/jnnp.2003.034447

[14] Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients [J].

Gultekin, SH ;

Rosenfeld, MR ;

Voltz, R ;

Eichen, J ;

Posner, JB ;

Dalmau, J .

BRAIN, 2000, 123 :1481-1494

[15] Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis [J].

Hughes, Ethan G. ;

Peng, Xiaoyu ;

Gleichman, Amy J. ;

Lai, Meizan ;

Zhou, Lei ;

Tsou, Ryan ;

Parsons, Thomas D. ;

Lynch, David R. ;

Dalmau, Josep ;

Balice-Gordon, Rita J. .

JOURNAL OF NEUROSCIENCE, 2010, 30 (17) :5866-5875

[16] Anti-NMDA receptor encephalitis in Japan [J].

Iizuka, T. ;

Sakai, F. ;

Ide, T. ;

Monzen, T. ;

Yoshii, S. ;

Iigaya, M. ;

Suzuki, K. ;

Lynch, D. R. ;

Suzuki, N. ;

Hata, T. ;

Dalmau, J. .

NEUROLOGY, 2008, 70 (07) :504-511

[17] Faciobrachial dystonic seizures: the influence of immunotherapy on seizure control and prevention of cognitive impairment in a broadening phenotype [J].

Irani, Sarosh R. ;

Stagg, Charlotte J. ;

Schott, Jonathan M. ;

Rosenthal, Clive R. ;

Schneider, Susanne A. ;

Pettingill, Philippa ;

Pettingill, Rosemary ;

Waters, Patrick ;

Thomas, Adam ;

Voets, Natalie L. ;

Cardoso, Manuel J. ;

Cash, David M. ;

Manning, Emily N. ;

Lang, Bethan ;

Smith, Shelagh J. M. ;

Vincent, Angela ;

Johnson, Michael R. .

BRAIN, 2013, 136 :3151-3162

[18] Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia [J].

Irani, Sarosh R. ;

Alexander, Sian ;

Waters, Patrick ;

Kleopa, Kleopas A. ;

Pettingill, Philippa ;

Zuliani, Luigi ;

Peles, Elior ;

Buckley, Camilla ;

Lang, Bethan ;

Vincent, Angela .

BRAIN, 2010, 133 :2734-2748

[19] N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes [J].

Irani, Sarosh R. ;

Bera, Katarzyna ;

Waters, Patrick ;

Zuliani, Luigi ;

Maxwell, Susan ;

Zandi, Michael S. ;

Friese, Manuel A. ;

Galea, Ian ;

Kullmann, Dimitri M. ;

Beeson, David ;

Lang, Bethan ;

Bien, Christian G. ;

Vincent, Angela .

BRAIN, 2010, 133 :1655-1667

[20] ANTI-NMDA RECEPTOR ENCEPHALITIS CAUSING PROLONGED NONCONVULSIVE STATUS EPILEPTICUS [J].

Johnson, Nicholas ;

Henry, Craig ;

Fessler, A. James ;

Dalmau, Josep .

NEUROLOGY, 2010, 75 (16) :1480-1482

← 1 2 3 4 5 →