Anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis show distinct patterns of brain glucose metabolism in 18F-fluoro-2-deoxy-d-glucose positron emission tomography

被引：74

作者：

Wegner, Florian ^{[1
]}

Wilke, Florian ^{[2
]}

Raab, Peter ^{[3
]}

Ben Tayeb, Said ^{[1
]}

Boeck, Anna-Lena ^{[1
]}

Haense, Cathleen ^{[4
]}

Trebst, Corinna ^{[1
]}

Voss, Elke ^{[1
]}

Schrader, Christoph ^{[1
]}

Logemann, Frank ^{[5
]}

Ahrens, Joerg ^{[5
]}

Leffler, Andreas ^{[5
]}

Rodriguez-Raecke, Rea ^{[1
]}

Dengler, Reinhard ^{[1
]}

Geworski, Lilli ^{[2
]}

Bengel, Frank M. ^{[4
]}

Berding, Georg ^{[4
]}

Stangel, Martin ^{[1
]}

Nabavi, Elham ^{[4
]}

机构：

[1] Hannover Med Sch, Dept Neurol, D-30625 Hannover, Germany

[2] Hannover Med Sch, Dept Med Phys, D-30625 Hannover, Germany

[3] Hannover Med Sch, Inst Neuroradiol, D-30625 Hannover, Germany

[4] Hannover Med Sch, Dept Nucl Med, D-30625 Hannover, Germany

[5] Hannover Med Sch, Dept Anesthesia & Crit Care Med, D-30625 Hannover, Germany

来源：

BMC NEUROLOGY | 2014年 / 14卷

关键词：

Anti-leucine rich glioma inactivated 1 protein (LGI1); Anti-N-methyl-D-aspartate (NMDA) receptor antibody; Paraneoplastic syndrome; Autoimmune limbic encephalitis; Brain glucose metabolism; 18F-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET); PARANEOPLASTIC LIMBIC ENCEPHALITIS; PET/CT FINDINGS; PROPOFOL ANESTHESIA; FDG-PET; AUTOANTIBODIES; ANTIBODIES; EPILEPSY; MRI; DISORDER; F-18-FDG;

D O I：

10.1186/1471-2377-14-136

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Pathogenic autoantibodies targeting the recently identified leucine rich glioma inactivated 1 protein and the subunit 1 of the N-methyl-D-aspartate receptor induce autoimmune encephalitis. A comparison of brain metabolic patterns in F-18-fluoro-2-deoxy-d-glucose positron emission tomography of anti-leucine rich glioma inactivated 1 protein and anti-N-methyl-D-aspartate receptor encephalitis patients has not been performed yet and shall be helpful in differentiating these two most common forms of autoimmune encephalitis. Methods: The brain F-18-fluoro-2-deoxy-d-glucose uptake from whole body positron emission tomography of six anti-N-methyl-D-aspartate receptor encephalitis patients and tour patients with anti-leucine rich glioma inactivated 1 protein encephalitis admitted to Hannover Medical School between 2008 and 2012 was retrospectively analyzed and compared to matched controls. Results: Group analysis of anti-N-methyl-D-aspartate encephalitis patients demonstrated regionally limited hypermetabolism in frontotemporal areas contrasting an extensive hypometabolism in parietal lobes, whereas the anti leucine rich glioma inactivated 1 protein syndrome was characterized by hypermetabolism in cerebellar, basal ganglia, occipital and precentral areas and minor frontomesial hypometabolism. Conclusions: This retrospective F-18-fluor-2-deoxy-d-glucose positron emission tomography study provides novel evidence for distinct brain metabolic patterns in patients with anti-leucine rich glioma inactivated 1 protein and anti N methyl-D-aspartate receptor encephalitis.

引用

页数：11

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