Molecular signatures in acute myeloid leukemia

被引:29
作者
Mrozek, Krzysztof [1 ]
Radmacher, Michael D. [1 ,2 ]
Bloomfield, Clara D. [1 ]
Marcucci, Guido [1 ,3 ]
机构
[1] Ohio State Univ, Dept Internal Med, Ctr Comprehens Canc, Div Hematol & Oncol, Columbus, OH 43210 USA
[2] Duke Univ, Med Ctr, Ctr Stat, CALGB, Durham, NC USA
[3] Ohio State Univ, Ctr Comprehens Canc, Dept Microbiol Virol Immunol & Med Genet, Div Human Canc Genet, Columbus, OH 43210 USA
关键词
acute myeloid leukemia; gene-expression profiling; microRNA; GENE-EXPRESSION SIGNATURE; MICRORNA EXPRESSION; NORMAL KARYOTYPE; CANCER; MUTATIONS; DISTINCT; ABNORMALITIES; PROFILES; CLASSIFICATION; CYTOGENETICS;
D O I
10.1097/MOH.0b013e3283257b42
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Acute myeloid leukemia (AML) is characterized by a high degree of heterogeneity with respect to chromosome abnormalities, gene mutations and changes in expression of multiple genes and microRNAs. In this article, we review the results of recent studies of AML that used microarray-based genome-wide gene-expression and microRNA-expression profiling. Recent findings Genome-wide analyses of gene expression and microRNA expression have revealed AML signatures that are closely associated with some, but not all, cytogenetic and molecular genetic subsets, helped in identification of novel biologic subtypes and led to characterization of molecular pathways involved in leukemogenesis. For some AML categories, namely core-binding factor AML and/or cytogenetically normal AML, gene-expression and microRNA-expression profiling provided prognostic information additional to that obtained from cytogenetics and analyses of gene mutations and single gene expression changes. Summary Gene-expression and microRNA-expression profiling not only has the potential to enhance our understanding of the disease biology, but also appears to constitute an applicable approach for outcome prediction and identification of novel therapeutic targets.
引用
收藏
页码:64 / 69
页数:6
相关论文
共 50 条
  • [31] Molecular pathway activation features of pediatric acute myeloid leukemia (AML) and acute lymphoblast leukemia (ALL) cells
    Petrov, Ivan
    Suntsova, Maria
    Mutorova, Olga
    Sorokin, Maxim
    Garazha, Andrew
    Ilnitskaya, Elena
    Spirin, Pavel
    Larin, Sergey
    Zhavoronkov, Alex
    Kovalchuk, Olga
    Prassolov, Vladimir
    Roumiantsev, Alexander
    Buzdin, Anton
    AGING-US, 2016, 8 (11): : 2936 - 2947
  • [32] Prognostically Important Molecular Markers in Cytogenetically Normal Acute Myeloid Leukemia
    Lin, Tara L.
    Smith, B. Douglas
    AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2011, 341 (05) : 404 - 408
  • [33] DNA Methylation Signatures Predict Cytogenetic Subtype and Outcome in Pediatric Acute Myeloid Leukemia (AML)
    Krali, Olga
    Palle, Josefine
    Backlin, Christofer L.
    Abrahamsson, Jonas
    Noren-Nystrom, Ulrika
    Hasle, Henrik
    Jahnukainen, Kirsi
    Jonsson, Olafur Gisli
    Hovland, Randi
    Lausen, Birgitte
    Larsson, Rolf
    Palmqvist, Lars
    Staffas, Anna
    Zeller, Bernward
    Nordlund, Jessica
    GENES, 2021, 12 (06)
  • [34] Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
    Blochl, Constantin
    Wang, Di
    Mayboroda, Oleg A.
    Lageveen-Kammeijer, Guinevere S. M.
    Wuhrer, Manfred
    CELL AND BIOSCIENCE, 2023, 13 (01)
  • [35] Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association
    Renneville, A.
    Boissel, N.
    Nibourel, O.
    Berthon, C.
    Helevaut, N.
    Gardin, C.
    Cayuela, J-M
    Hayette, S.
    Reman, O.
    Contentin, N.
    Bordessoule, D.
    Pautas, C.
    de Botton, S.
    de Revel, T.
    Terre, C.
    Fenaux, P.
    Thomas, X.
    Castaigne, S.
    Dombret, H.
    Preudhomme, C.
    LEUKEMIA, 2012, 26 (06) : 1247 - 1254
  • [36] Metabolomics in acute myeloid leukemia
    Wojcicki, Anna V.
    Kasowski, Maya M.
    Sakamoto, Kathleen M.
    Lacayo, Norman
    MOLECULAR GENETICS AND METABOLISM, 2020, 130 (04) : 230 - 238
  • [37] Integrative Meta-Analysis of Differential Gene Expression in Acute Myeloid Leukemia
    Miller, Brady G.
    Stamatoyannopoulos, John A.
    PLOS ONE, 2010, 5 (03):
  • [38] Molecular biology and prognostic value in acute myeloid leukemia
    Llopis, Laura
    Boissel, Nicolas
    Nibourel, Olivier
    Wemeau, Mathieu
    Renneville, Aline
    Dombret, Herve
    Preudhomme, Claude
    HEMATOLOGIE, 2009, 15 (06): : 426 - 443
  • [39] Effect of therapy-related acute myeloid leukemia on the outcome of patients with acute myeloid leukemia
    Santo, Ana Espirito
    Chacim, Sergio
    Ferreira, Isabel
    Leite, Luis
    Moreira, Claudia
    Pereira, Dulcineia
    Brito, Margarida Dantas
    Nunes, Marta
    Domingues, Nelson
    Oliveira, Isabel
    Moreira, Ilidia
    Martins, Angelo
    Viterbo, Luisa
    Mariz, Jose Mario
    Medeiros, Rui
    ONCOLOGY LETTERS, 2016, 12 (01) : 262 - 268
  • [40] Aging and comprehensive molecular profiling in acute myeloid leukemia
    Li, Jian-Feng
    Cheng, Wen-Yan
    Lin, Xiang-Jie
    Wen, Li-Jun
    Wang, Kai
    Zhu, Yong-Mei
    Zhu, Hong-Ming
    Chen, Xin-Jie
    Zhang, Yu-Liang
    Yin, Wei
    Zhang, Jia-Nan
    Yi, Xiao
    Zhang, Fan
    Weng, Xiang-Qin
    Wang, Sheng-Yue
    Jiang, Lu
    Wu, Hui-Yi
    Ren, Jia-Qi
    Lin, Xiao-Jing
    Qiao, Niu
    Dai, Yu-Ting
    Fang, Hai
    Tan, Yun
    Sun, Xiao-Jian
    Lv, Gang
    Yan, Xiao-Yu
    Chen, Su-Ning
    Chen, Zhu
    Jin, Jie
    Wu, De-Pei
    Ren, Rui-Bao
    Chen, Sai-Juan
    Shen, Yang
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2024, 121 (10)