Genetic Background Influences Nicotine-induced Conditioned Place Preference and Place Aversion in Mice

被引：5

作者：

Ise, Yuya ^{[1
,2
]}

Mori, Tomohisa ^{[2
]}

Katayama, Shirou ^{[1
]}

Suzuki, Tsutomu ^{[2
]}

Wang, Tzu-Chueh ^{[3
]}

机构：

[1] Nippon Med Coll Hosp, Sect Pharmaceut Serv, Tokyo, Japan

[2] Hoshi Univ, Dept Toxicol, Sch Pharm & Pharmaceut Sci, Tokyo 1428501, Japan

[3] Chia Nan Univ Pharm & Sci, Dept Pharm, Tainan, Taiwan

来源：

JOURNAL OF NIPPON MEDICAL SCHOOL | 2014年 / 81卷 / 01期

关键词：

conditioned place preference paradigm; nicotine; mecamylamine; genetic difference; mice; RECEPTORS; MORPHINE;

D O I：

10.1272/jnms.81.53

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study was designed to determine whether genetic differences influence the rewarding effects of nicotine in 4 inbred strains of mice (DBA/2, BALB/c, C3H, and C57BL/6). Nicotine (subcutaneous) induced a place preference in DBA/2 and BALB/c mice but a place aversion in C57BL/6 mice. A low dose of nicotine produced a significant place preference, whereas a high dose of nicotine produced place aversion in C3H mice. These effects were completely reversed by the nicotinic receptor antagonist mecamylamine. These results strongly suggest that a conditioned state, such as rewarding effects or aversive effects, can be influenced by genetic background.

引用

页码：53 / 56

页数：4

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