Quantitative imaging biomarkers in neuro-oncology

被引：86

作者：

Waldman, Adam D. ^{[1
]}

Jackson, Alan ^{[2
]}

Price, Stephen J. ^{[3
]}

Clark, Christopher A. ^{[4
]}

Booth, Thomas C. ^{[5
]}

Auer, Dorothee P. ^{[6
]}

Tofts, Paul S. ^{[7
]}

Collins, David J. ^{[8
]}

Leach, Martin O. ^{[8
]}

Rees, Jeremy H. ^{[9
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Imaging, London, England

[2] Manchester Canc Res Ctr, Manchester, Lancs, England

[3] Addenbrookes Hosp, Cambridge, England

[4] UCL, Inst Child Hlth London, London, England

[5] Royal Free Hosp, London NW3 2QG, England

[6] Univ Nottingham, Nottingham NG7 2RD, England

[7] Brighton & Sussex Med Sch, Brighton, E Sussex, England

[8] Royal Marsden Hosp, London SW3 6JJ, England

[9] UCL, Inst Neurol, London, England

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2009年 / 6卷 / 08期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; MAGNETIC-RESONANCE-SPECTROSCOPY; CEREBRAL BLOOD-VOLUME; HIGH-GRADE GLIOMAS; CONTRAST-ENHANCED MR; APPARENT DIFFUSION-COEFFICIENT; RECURRENT MALIGNANT GLIOMAS; GLUCOSE METABOLIC-RATE; VASOGENIC BRAIN EDEMA; SHORT ECHO TIME;

D O I：

10.1038/nrclinonc.2009.92

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Conventional structural imaging provides limited information on tumor characterization and prognosis. Advances in neurosurgical techniques, radiotherapy planning and novel drug treatments for brain tumors have generated increasing need for reproducible, noninvasive, quantitative imaging biomarkers. This review considers the role of physiological MRI and PET molecular imaging in understanding metabolic processes associated with tumor growth, blood flow and ultrastructure. we address the utility of various techniques in distinguishing between tumors and non-neoplastic processes, in tumor grading, in defining anatomical relationships between tumor and eloquent brain regions and in determining the biological substrates of treatment response. Much of the evidence is derived from limited case series in individual centers. Despite their 'added value', the effect of these techniques as an adjunct to structural imaging in clinical research and practice remains limited.

引用

页码：445 / 454

页数：10