Broadly neutralizing plasma antibodies effective against autologous circulating viruses in infants with multivariant HIV-1 infection

被引：23

作者：

Mishra, Nitesh ^{[1
]}

Sharma, Shaifali ^{[1
]}

Dobhal, Ayushman ^{[1
]}

Kumar, Sanjeev ^{[1
,4
]}

Chawla, Himanshi ^{[1
,5
,6
]}

Singh, Ravinder ^{[2
]}

Makhdoomi, Muzamil Ashraf ^{[1
,7
]}

Das, Bimal Kumar ^{[2
]}

Lodha, Rakesh ^{[3
]}

Kabra, Sushil Kumar ^{[3
]}

Luthra, Kalpana ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India

[2] All India Inst Med Sci, Dept Microbiol, New Delhi 110029, India

[3] All India Inst Med Sci, Dept Pediat, New Delhi 110029, India

[4] Int Ctr Genet Engn & Biotechnol, ICGEB Emory Vaccine Ctr, New Delhi, India

[5] Univ Southampton, Biol Sci, Southampton SO17 IBJ, Hants, England

[6] Univ Southampton, Inst Life, Southampton SO17 IBJ, Hants, England

[7] Cluster Univ, Govt Coll Women, Dept, Srinagar, India

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

关键词：

EPITOPE; IDENTIFICATION; EVOLUTION; THERAPY; LINEAGE; VIREMIA;

D O I：

10.1038/s41467-020-18225-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Broadly neutralizing antibodies (bnAbs) develop in a subset of HIV-1 infected individuals over 2-3 years of infection. Infected infants develop plasma bnAbs frequently and as early as 1-year post-infection suggesting factors governing bnAb induction in infants are distinct from adults. Understanding viral characteristics in infected infants with early bnAb responses will provide key information about antigenic triggers driving B cell maturation pathways towards induction of bnAbs. Herein, we evaluate the presence of plasma bnAbs in a cohort of 51 HIV-1 Glade-C infected infants and identify viral factors associated with early bnAb responses. Plasma bnAbs targeting V2-apex on the env are predominant in infant elite and broad neutralizers. Circulating viral variants in infant elite neutralizers are susceptible to V2-apex bnAbs. In infant elite neutralizers, multivariant infection is associated with plasma bnAbs targeting diverse autologous viruses. Our data provides information supportive of polyvalent vaccination approaches capable of inducing V2-apex bnAbs against HIV-1.

引用

页数：11

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