The Effect of Zinc Supplementation on Insulin Resistance in Obese Subjects: a Systematic Review

被引：41
作者：
Climaco Cruz, Kyria Jayanne [1 ]
Silva Morais, Jennifer Beatriz [1 ]
Soares de Oliveira, Ana Raquel [1 ]
Severo, Juliana Soares [1 ]
Marreiro, Dilina do Nascimento [1 ]
机构：
[1] Univ Fed Piaui, Dept Nutr, Campus Minister Petronio Portela, Teresina, Piaui, Brazil
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2017年 / 176卷 / 02期
关键词：
Obesity; Zinc; Insulin resistance; GENE-EXPRESSION; INFLAMMATION; SENSITIVITY; MARKERS; LEPTIN;
D O I：
10.1007/s12011-016-0835-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Obesity is a chronic disease characterized by excessive accumulation of body fat and the presence of metabolic disorders such as insulin resistance. In this sense, zinc is an important nutrient that stimulates insulin secretion and increases sensitivity to insulin. The aim of this study was to investigate the effect of zinc supplementation on insulin resistance in obese subjects through a systematic review of the available clinical trials. The search for articles was conducted using the PubMed, SciVerse Scopus, SciVerse ScienceDirect, and Cochrane databases, on May 25, 2016, by two authors independently. The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) were followed in the conduct of this review. The Cochrane Collaboration tool was used to assess the risk of bias of the trials included in this review. After screening of the articles, six clinical trials were included in this systematic review. The scientific evidence presented in this systematic review shows that zinc supplementation improves insulin resistance in obese individuals of both sexes.
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收藏
页码：239 / 243
页数：5
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