Chitinase 3-like 1 is associated with the response to interferon-beta treatment in multiple sclerosis

被引：20

作者：

Matute-Blanch, Clara ^{[1
]}

Rio, Jordi ^{[1
]}

Villar, Luisa M. ^{[2
]}

Midaglia, Luciana ^{[1
]}

Malhotra, Sunny ^{[1
]}

Alvarez-Cermeno, Jose C. ^{[2
]}

Vidal-Jordana, Angela ^{[1
]}

Montalban, Xavier ^{[1
]}

Comabella, Manuel ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Hosp Univ Vall Hebron, Ctr Esclerosi Multiple Catalunya Cemcat, Inst Recerca Vall Hebron VHIR,Servei Neurol Neuro, Barcelona, Spain

[2] Hosp Univ Ramon & Cajal, Inst Ramon & Cajal Invest Sanitaria, Dept Neurol & Immunol, Madrid, Spain

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 303卷

关键词：

Chitinase; 3-like; 1; Interferon-beta; Glatiramer acetate; Biomarkers; Multiple sclerosis; BIOMARKER; PREDICT; FAMILY;

D O I：

10.1016/j.jneuroim.2016.12.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chitinase 3-like 1 (CHI3L1) plays a prognostic role in patients with multiple sclerosis (MS). Here, we investigated a potential association between CHI3L1 and the response to interferon-beta (IFN beta) and glatiramer acetate (GA). Serum CHI3L1 levels were measured by ELISA in 117 relapsing-remitting MS (RRMS) patients, 76 IFN beta-treated and 41 GA-treated patients. CHI3L1 levels were increased by GA (p = 0.014) but unchanged by IFN beta (p =0.830). CHI3L1 was associated with IFN beta, response and levels were higher in non-responder group (p 0.020), while GA showed no responder effect (p = 0.943). These results suggest a role for CHI3L1 as response biomarker to IFN beta in RRMS patients. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：62 / 65

页数：4

共 11 条

[1] Chitinase 3-like 1 plasma levels are increased in patients with progressive forms of multiple sclerosis [J].

Canto, E. ;

Reverter, F. ;

Morcillo-Suarez, C. ;

Matesanz, F. ;

Fernandez, O. ;

Izquierdo, G. ;

Vandenbroeck, K. ;

Rodriguez-Antigueedad, A. ;

Urcelay, E. ;

Arroyo, R. ;

Otaegui, D. ;

Olascoaga, J. ;

Saiz, A. ;

Navarro, A. ;

Sanchez, A. ;

Dominguez, C. ;

Caminero, A. ;

Horga, A. ;

Tintore, M. ;

Montalban, X. ;

Comabella, M. .

MULTIPLE SCLEROSIS JOURNAL, 2012, 18 (07) :983-990

[2] Chitinase 3-like 1: prognostic biomarker in clinically isolated syndromes [J].

Canto, Ester ;

Tintore, Mar ;

Villar, Luisa M. ;

Costa, Carme ;

Nurtdinov, Ramil ;

Alvarez-Cermeno, Jose C. ;

Arrambide, Georgina ;

Reverter, Ferran ;

Deisenhammer, Florian ;

Hegen, Harald ;

Khademi, Mohsen ;

Olsson, Tomas ;

Tumani, Hayrettin ;

Rodriguez-Martin, Eulalia ;

Piehl, Fredrik ;

Bartos, Ales ;

Zimova, Denisa ;

Kotoucova, Jolana ;

Kuhle, Jens ;

Kappos, Ludwig ;

Antonio Garcia-Merino, Juan ;

Jos Sanchez, Antonio ;

Saiz, Albert ;

Blanco, Yolanda ;

Hintzen, Rogier ;

Jafari, Naghmeh ;

Brassat, David ;

Lauda, Florian ;

Roesler, Romy ;

Rejdak, Konrad ;

Papuc, Ewa ;

de Andres, Clara ;

Rauch, Stefan ;

Khalil, Michael ;

Enzinger, Christian ;

Galimberti, Daniela ;

Scarpini, Elio ;

Teunissen, Charlotte ;

Sanchez, Alex ;

Rovira, Alex ;

Montalban, Xavier ;

Comabella, Manuel .

BRAIN, 2015, 138 :918-931

[3]

HAKALA BE, 1993, J BIOL CHEM, V268, P25803

[4] Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis [J].

Hinsinger, G. ;

Galeotti, N. ;

Nabholz, N. ;

Urbach, S. ;

Rigau, V. ;

Demattei, C. ;

Lehmann, S. ;

Camu, W. ;

Labauge, P. ;

Castelnovo, G. ;

Brassat, D. ;

Loussouarn, D. ;

Salou, M. ;

Laplaud, D. ;

Casez, O. ;

Bockaert, J. ;

Marin, P. ;

Thouvenot, E. .

MULTIPLE SCLEROSIS JOURNAL, 2015, 21 (10) :1251-1261

[5]

Johansen JS, 2006, DAN MED BULL, V53, P172

[6]

Kawada Mayumi, 2007, Keio Journal of Medicine, V56, P21, DOI 10.2302/kjm.56.21

[7] Cerebrospinal fluid levels of chitinase 3-like 1 and neurofilament light chain predict multiple sclerosis development and disability after optic neuritis [J].

Modvig, S. ;

Degn, M. ;

Roed, H. ;

Sorensen, T. L. ;

Larsson, H. B. W. ;

Langkilde, A. R. ;

Frederiksen, J. L. ;

Sellebjerg, F. .

MULTIPLE SCLEROSIS JOURNAL, 2015, 21 (14) :1761-1770

[8] Chitotriosidase, a chitinase, and the 39-kDa human cartilage glycoprotein, a chitin-binding lectin, are homologues of family 18 glycosyl hydrolases secreted by human macrophages [J].

Renkema, GH ;

Boot, RG ;

Au, FL ;

Donker-Koopman, WE ;

Strijland, A ;

Muijsers, AO ;

Hrebicek, M ;

Aerts, JMFG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1998, 251 (1-2) :504-509

[9] Assessment of different treatment failure criteria in a cohort of relapsing-remitting multiple sclerosis patients treated with interferon β:: Implications for clinical trials [J].

Río, J ;

Nos, C ;

Tintoré, M ;

Borrás, C ;

Galán, I ;

Combella, M ;

Montalban, X .

ANNALS OF NEUROLOGY, 2002, 52 (04) :400-406

[10] Measures in the first year of therapy predict the response to interferon β in MS [J].

Rio, J. ;

Castillo, J. ;

Rovira, A. ;

Tintore, M. ;

Sastre-Garriga, J. ;

Horga, A. ;

Nos, C. ;

Comabella, M. ;

Aymerich, X. ;

Montalban, X. .

MULTIPLE SCLEROSIS, 2009, 15 (07) :848-853

← 1 2 →