Associations of maternal macronutrient intake during pregnancy with infant BMI peak characteristics and childhood BMI

被引：52

作者：

Chen, Ling-Wei ^{[1
]}

Aris, Izzuddin M. ^{[5
]}

Bernard, Jonathan Y. ^{[5
]}

Tint, Mya-Thway ^{[2
]}

Colega, Marjorelee ^{[5
]}

Gluckman, Peter D. ^{[5
,7
]}

Tan, Kok Hian ^{[8
,10
]}

Shek, Lynette Pei-Chi ^{[1
]}

Chong, Yap-Seng ^{[2
,5
]}

Yap, Fabian ^{[9
,10
]}

Godfrey, Keith M. ^{[11
,12
,13
]}

van Dam, Rob M. ^{[3
,4
,14
]}

Chong, Mary Foong-Fong ^{[4
,5
,6
]}

Lee, Yung Seng ^{[1
,5
,15
]}

机构：

[1] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Pediat, Singapore, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Obstet & Gynecol, Singapore, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore

[4] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[5] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Singapore, Singapore

[6] Agcy Sci Technol & Res, Singapore Inst Clin Sci, Clin Nutr Res Ctr, Singapore, Singapore

[7] Univ Auckland, Liggins Inst, Auckland, New Zealand

[8] KK Womens & Childrens Hosp, Dept Maternal Fetal Med, Singapore, Singapore

[9] KK Womens & Childrens Hosp, Dept Pediat Endocrinol, Singapore, Singapore

[10] Duke Natl Univ Singapore, Grad Sch Med, Singapore, Singapore

[11] Univ Southampton, Med Res Council Lifecourse Epidemiol Unit, Southampton, Hants, England

[12] Univ Southampton, Natl Inst Hlth Res, Southampton Biomed Res Ctr, Southampton, Hants, England

[13] Univ Hosp Southampton Natl Hlth Serv Fdn Trust, Southampton, Hants, England

[14] Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA

[15] Natl Univ Hlth Syst, Khoo Teck Puat Natl Univ Childrens Med Inst, Singapore, Singapore

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2017年 / 105卷 / 03期

基金：

英国医学研究理事会;

关键词：

adiposity; carbohydrate; childhood BMI; growth modeling; infancy BMI peak; macronutrient; developmental origins; maternal diet; pregnancy diet; sugar; GESTATIONAL DIABETES-MELLITUS; 1ST 1,000 DAYS; BODY-COMPOSITION; ETHNIC-DIFFERENCES; METABOLIC SYNDROME; BIRTH-WEIGHT; ADIPOSITY; OBESITY; RISK; WOMEN;

D O I：

10.3945/ajcn.116.148270

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Infant body mass index (BMI) peak characteristics and early childhood BMI are emerging markers of future obesity and cardiometabolic disease risk, but little is known about their maternal nutritional determinants. Objective: We investigated the associations of maternal macronutrient intake with infant BMI peak characteristics and childhood BMI in the Growing Up in Singapore Towards healthy Outcomes study. Design: With the use of infant BMI data from birth to age 18 mo, infant BMI peak characteristics [age (in months) and magnitude (BMIpeak; in kg/m(2)) at peak and prepeak velocities] were derived from subject-specific BMI curves that were fitted with the use of mixed-effects model with a natural cubic spline function. Associations of maternal macronutrient intake (assessed by using a 24-h recall during late gestation) with infant BMI peak characteristics (n = 910) and BMI z scores at ages 2, 3, and 4 y were examined with the use of multivariable linear regression. Results: Mean absolute maternal macronutrient intakes (percentages of energy) were 72 g protein (15.6%), 69 g fat (32.6%), and 238 g carbohydrate (51.8%). A 25-g (similar to 100-kcal) increase in maternal carbohydrate intake was associated with a 0.01/mo (95% CI: 0.0003, 0.01/mo) higher prepeak velocity and a 0.04 (95% CI: 0.01, 0.08) higher BMIpeak. These associations were mainly driven by sugar intake, whereby a 25-g increment of maternal sugar intake was associated with a 0.02/mo (95% CI: 0.01, 0.03/mo) higher infant prepeak velocity and a 0.07 (95% CI: 0.01, 0.13) higher BMIpeak. Higher maternal carbohydrate and sugar intakes were associated with a higher offspring BMI z score at ages 2-4 y. Maternal protein and fat intakes were not consistently associated with the studied outcomes. Conclusion: Higher maternal carbohydrate and sugar intakes are associated with unfavorable infancy BMI peak characteristics and higher early childhood BMI.

引用

页码：705 / 713

页数：9

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