THE UPREGULATION OF PFKFB3/ PDK4 ENHANCES OVARIAN CANCER STEMNESS PROPERTIES IN TUMOR PROGRESSION

被引：0
|
作者：
Jiang, Y. [1 ]
Siu, M. K. [1 ]
Wang, J. [1 ]
Leung, T. H. [1 ]
Ngu, S. F. [1 ]
Chan, D. W. [1 ]
Cheung, A. N. [2 ]
Ngan, H. Y. [1 ]
Chan, K. K. [1 ]
机构：
[1] Univ Hong Kong, Dept Obstet & Gynaecol, Hong Kong, Peoples R China
[2] Univ Hong Kong, Dept Pathol, Hong Kong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2018年 / 28卷
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
IGCS8-0478
引用
收藏
页码：137 / 137
页数：1
相关论文
共 50 条
  • [21] Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer
    Wang, Jinghao
    Qian, Yu
    Gao, Meiyan
    CANCER MANAGEMENT AND RESEARCH, 2019, 11 : 251 - 262
  • [22] Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair
    Xiao, Yinan
    Wu, Yu
    Wang, Qilong
    Li, Mo
    Deng, Chaolin
    Gu, Xiaoyang
    CELL COMMUNICATION AND SIGNALING, 2025, 23 (01)
  • [23] Anti-oncogenic activity of a novel PDK4 inhibitor in bladder cancer by suppressing the H-Ras and cancer stemness
    Kim, Chul Jang
    Terado, Tokio
    Tambe, Yukihiro
    Nakano, Hirofumi
    Kawauchi, Akihiro
    Inoue, Hirokazu
    CANCER SCIENCE, 2018, 109 : 577 - 577
  • [24] Upregulation of SNHG3 expression associated with poor prognosis and enhances malignant progression of ovarian cancer
    Hong, Lan
    Chen, Wangsheng
    Wu, Dongcai
    Wang, Yifeng
    CANCER BIOMARKERS, 2018, 22 (03) : 367 - 374
  • [25] Upregulation of glycolytic enzyme PFKFB3 by deubiquitinase OTUD4 promotes cardiac fibrosis post myocardial infarction
    Feizuo Wang
    Xiaojian Yin
    Yuan-Ming Fan
    Xinyao Zhang
    Chao Ma
    Keke Jia
    Wei Zhou
    Zongxiang Tang
    Lian-Wen Qi
    Jia Li
    Journal of Molecular Medicine, 2023, 101 : 743 - 756
  • [26] Deficiency of TOP1MT enhances glycolysis through the stimulation of PDK4 expression in gastric cancer
    Hongqiang Wang
    Xutao Sun
    Chen Yang
    Ziqi Li
    Danwen Jin
    Wenwen Zhu
    Ze Yu
    Cancer & Metabolism, 12
  • [27] PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells
    Yan, Siyuan
    Zhou, Nan
    Zhang, Deru
    Zhang, Kaile
    Zheng, Wenao
    Bao, Yonghua
    Yang, Wancai
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (21)
  • [28] Deficiency of TOP1MT enhances glycolysis through the stimulation of PDK4 expression in gastric cancer
    Wang, Hongqiang
    Sun, Xutao
    Yang, Chen
    Li, Ziqi
    Jin, Danwen
    Zhu, Wenwen
    Yu, Ze
    CANCER & METABOLISM, 2024, 12 (01)
  • [29] AICAR enhances the cytotoxicity of PFKFB3 inhibitor in an AMPK signaling-independent manner in colorectal cancer cells
    Yan, Siyuan
    Yuan, Dongdong
    Li, Qianqian
    Li, Shi
    Zhang, Fan
    MEDICAL ONCOLOGY, 2022, 39 (01)
  • [30] AICAR enhances the cytotoxicity of PFKFB3 inhibitor in an AMPK signaling-independent manner in colorectal cancer cells
    Siyuan Yan
    Dongdong Yuan
    Qianqian Li
    Shi Li
    Fan Zhang
    Medical Oncology, 2022, 39
12345