Macrophage Depletion Prior to Neospora caninum Infection Results in Severe Neosporosis in Mice

被引：21

作者：

Abe, Chisa ^{[1
]}

Tanaka, Sachi ^{[1
,2
]}

Ihara, Fumiaki ^{[1
]}

Nishikawa, Yoshifumi ^{[1
]}

机构：

[1] Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 080, Japan

[2] Shinshu Univ, Fac Agr, Kamiina, Nagano, Japan

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2014年 / 21卷 / 08期

关键词：

TOXOPLASMA-GONDII; GAMMA-INTERFERON; INNATE IMMUNITY; CELLS; DOGS;

D O I：

10.1128/CVI.00082-14

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We observed that murine macrophages showed greater activation and increased interleukin 6 (IL-6), IL-12p40, and interferon gamma (IFN-gamma) production during Neospora caninum infection. Many macrophages migrated to the site of infection. Furthermore, macrophage-depleted mice exhibited increased sensitivity to N. caninum infection. This study indicates that macrophages are required for achieving protective immunity against N. caninum.

引用

页码：1185 / 1188

页数：4

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