Unique features of long non-coding RNA biogenesis and function

被引：2981

作者：

Quinn, Jeffrey J. ^{[1
,2
,3
]}

Chang, Howard Y. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Ctr Personal Dynam Regulomes, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Bioengn, Stanford, CA 94305 USA

[3] Sch Engn, Stanford, CA 94305 USA

来源：

NATURE REVIEWS GENETICS | 2016年 / 17卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CRYPTIC UNSTABLE TRANSCRIPTS; MESSENGER-RNA; CIRCULAR RNAS; DIVERGENT TRANSCRIPTION; PERVASIVE TRANSCRIPTION; ANTISENSE TRANSCRIPTION; COMPUTATIONAL ANALYSIS; GENE-REGULATION; CELL-FATE; EXPRESSION;

D O I：

10.1038/nrg.2015.10

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Long non-coding RNAs (lncRNAs) are a diverse class of RNAs that engage in numerous biological processes across every branch of life. Although initially discovered as mRNA-like transcripts that do not encode proteins, recent studies have revealed features of lncRNAs that further distinguish them from mRNAs. In this Review, we describe special events in the lifetimes of lncRNAs - before, during and after transcription - and discuss how these events ultimately shape the unique characteristics and functional roles of lncRNAs.

引用

页码：47 / 62

页数：16

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