Enantioselective C-H Annulation of Indoles with Diazo Compounds through a Chiral Rh(III) Catalyst

被引：81

作者：

Chen, Xiaohong ^{[1
]}

Yang, Shujing ^{[1
]}

Li, Helong ^{[1
]}

Wang, Bo ^{[1
]}

Song, Guoyong ^{[1
]}

机构：

[1] Beijing Forestry Univ, Beijing Key Lab Lignocellulos Chem, Beijing 100083, Peoples R China

来源：

ACS CATALYSIS | 2017年 / 7卷 / 04期

关键词：

enantioselective; C-H annulation; rhodium; indole; diazo ester; FRIEDEL-CRAFTS ALKYLATION; CYCLOPENTADIENYL LIGANDS; BIARYL COMPOUNDS; BOND ADDITION; N BOND; FUNCTIONALIZATION; ACTIVATION; ALKENES; ALKYNES; COMPLEXES;

D O I：

10.1021/acscatal.7b00104

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The asymmetric C-H annulation of O-pivaloyl 1-indolehydroxamic acid with donor/acceptor diazo compounds has been achieved for the first time, to the best of our knowledge, by using a rhodium catalyst embedded in a chiral binaphthyl backbone. This protocol constitutes a straightforward route for the synthesis of a new family of 1,2-dihydro-3H-imidazo[1,5-a]indol-3-one derivatives having a quaternary carbon stereocenter in high yields and excellent enantioselectivity (up to 98:2 er).

引用

页码：2392 / 2396

页数：5

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