Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults

被引：156

作者：

McElhaney, Janet E. ^{[1
,2
]}

Ewen, Catherine ^{[3
]}

Zhou, Xin

Kane, Kevin R. ^{[3
]}

Xie, Dongxu

Hager, W. David ^{[4
]}

Barry, Mary Beth ^{[4
]}

Kleppinger, Alison ^{[5
]}

Wang, Yazhen ^{[6
]}

Bleackley, R. Chris ^{[7
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Ctr Immunotherapy Canc & Infect Dis, Sch Med,Dept Immunol, Farmington, CT 06030 USA

[2] Univ British Columbia, Dept Med, Vancouver, BC V5Z 1L8, Canada

[3] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2H7, Canada

[4] Univ Connecticut, Sch Med, Pat & Jim Calhoun Cardiol Ctr, Farmington, CT 06030 USA

[5] Univ Connecticut, Sch Med, Dept Med, UConn Ctr Aging, Farmington, CT 06030 USA

[6] Univ Connecticut, Dept Stat, Storrs, CT 06269 USA

[7] Univ Alberta, Dept Biochem, Edmonton, AB T6G 2H7, Canada

来源：

VACCINE | 2009年 / 27卷 / 18期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

Granzyme B; Antibody; Influenza vaccination; CD8(+) T-CELLS; RESPIRATORY SYNCYTIAL VIRUS; PLACEBO-CONTROLLED TRIAL; ELDERLY INDIVIDUALS; UNITED-STATES; A-VIRUS; EFFICACY; MEMORY; IMMUNIZATION; ANTIBODY;

D O I：

10.1016/j.vaccine.2009.01.136

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study Compared serum antibody titers and granzyme B (GrzB) levels in virus-stimulated peripheral blood mononuclear cells following influenza vaccination. Twelve of 239 older adults who subsequently developed laboratory-diagnosed influenza illness (LDI) had significantly lower GrzB levels compared to subjects without LDI (p=0.004). Eight subjects with LDI in the previous year showed an enhanced GrzB response to vaccination (p = 0.02). Serum antibody titers following vaccination did not distinguish those older adults who developed LDI from those who did not. These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2418 / 2425

页数：8

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