Fasting and postprandial levels of a novel anorexigenic peptide nesfatin in childhood obesity

被引:14
作者
Anik, Ahmet [1 ]
Catli, Gonul [1 ]
Abaci, Ayhan [1 ]
Kume, Tuncay [2 ]
Bober, Ece [1 ]
机构
[1] Dokuz Eylul Univ, Dept Pediat Endocrinol, Fac Med, TR-35340 Izmir, Turkey
[2] Dokuz Eylul Univ, Dept Biochem, Fac Med, TR-35340 Izmir, Turkey
关键词
childhood; insulin resistance; nesfatin; obesity; BODY-MASS INDEX; ADIPOSE-TISSUE; FOOD-INTAKE; CHILDREN; ADOLESCENTS; ENDOCRINE; ADIPOKINE;
D O I
10.1515/jpem-2013-0475
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Nesfatin-1, a recently discovered anorexigenic peptide, is expressed in several tissues, including pancreatic islet cells and central nervous system. However, its pathophysiological role in the development of obesity and insulin resistance remains unknown. Aim: To investigate the possible involvement of nesfatin-1 in the pathogenesis of childhood obesity, we examined the relationship between fasting and postprandial nesfatin-1 concentrations and metabolic/antropometric parameters in obese children. Material and methods: The study included obese children with a body mass index >95th percentile. Fasting serum glucose, insulin, lipid profile, fasting and postprandial (120th min) nesfatin-1 levels were measured to evaluate the metabolic parameters. Different cutoff values for prepubertal and pubertal stages were used to determine the status of insulin resistance (HOMA-IR) (prepubertal >2.5, pubertal >4). The percentage of body fat was measured using bioelectric impedance analysis. Results: Seventy-one obese children were included in this study. There was no statistically significant difference between fasting and postprandial nesfatin-1 levels in obese subjects (0.70 +/- 0.15 and 0.69 +/- 0.14 ng/mL, p>0.05, respectively). Insulin resistance was observed in 58% (41/71) of the cases. There was no significant difference in either fasting or postprandial serum nesfatin-1 levels between the insulin-resistant and non-resistant groups (p>0.05). There was no correlation between fasting and postprandial serum nesfatin-1 levels and anthropometric and metabolic parameters in insulin-resistant and nonresistant groups. Conclusions: In this study, there was no significant increase in the postprandial level of nesfatin-1. This observation suggested that oral glucose load in obese children may not be sufficient for nesfatin-1 response and that nesfatin-1 may not have an effect as a short-term regulator of food intake.
引用
收藏
页码:623 / 628
页数:6
相关论文
共 28 条
[1]   The relation of serum nesfatin-1 level with metabolic and clinical parameters in obese and healthy children [J].
Abaci, Ayhan ;
Catli, Gonul ;
Anik, Ahmet ;
Kume, Tuncay ;
Bober, Ece .
PEDIATRIC DIABETES, 2013, 14 (03) :189-195
[2]  
Amer Diabet Assoc, 2005, DIABETES CARE, V28, pS37
[3]   Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
[4]   Nesfatin-1 and other hormone alterations in polycystic ovary syndrome [J].
Deniz, Rulin ;
Gurates, Bilgin ;
Aydin, Suleyman ;
Celik, Husnu ;
Sahin, Ibrahim ;
Baykus, Yakup ;
Catak, Zekiye ;
Aksoy, Aziz ;
Citil, Cihan ;
Gungor, Sami .
ENDOCRINE, 2012, 42 (03) :694-699
[5]   Nucleobindin-2/nesfatin in the endocrine pancreas: distribution and relationship to glycaemic state [J].
Foo, Kylie S. ;
Brauner, Hanna ;
Ostenson, Claes-Goran ;
Broberger, Christian .
JOURNAL OF ENDOCRINOLOGY, 2010, 204 (03) :255-263
[6]  
Genuth S, 2003, DIABETES CARE, V26, P3160
[7]   Nesfatin-1 exerts a direct, glucose-dependent insulinotropic action on mouse islet β- and MIN6 cells [J].
Gonzalez, Ronald ;
Reingold, Benjamin K. ;
Gao, Xiaodong ;
Gaidhu, Mandeep P. ;
Tsushima, Robert G. ;
Unniappan, Suraj .
JOURNAL OF ENDOCRINOLOGY, 2011, 208 (03) :R9-R16
[8]   Waist circumference percentiles for 7- to 17-year-old Turkish children and adolescents [J].
Hatipoglu, Nihal ;
Ozturk, Ahmet ;
Mazicioglu, Mumtaz M. ;
Kurtoglu, Selim ;
Seyhan, Selda ;
Lokoglu, Fikret .
EUROPEAN JOURNAL OF PEDIATRICS, 2008, 167 (04) :383-389
[9]   Distributions and trends of serum lipid levels among United States children and adolescents ages 4-19 years: Data from the third National Health and Nutrition Examination Survey [J].
Hickman, TB ;
Briefel, RR ;
Carroll, MD ;
Rifkind, BM ;
Cleeman, JI ;
Maurer, KR ;
Johnson, CL .
PREVENTIVE MEDICINE, 1998, 27 (06) :879-890
[10]   Nesfatin-1 exerts long-term effect on food intake and body temperature [J].
Koenczoel, K. ;
Pinter, O. ;
Ferenczi, S. ;
Varga, J. ;
Kovacs, K. ;
Palkovits, M. ;
Zelena, D. ;
Toth, Z. E. .
INTERNATIONAL JOURNAL OF OBESITY, 2012, 36 (12) :1514-1521