Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

被引：114

作者：

Liu, Chunzhao ^{[1
]}

Zhao, Yan

Wang, Yuchun

机构：

[1] Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100080, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 2006年 / 72卷 / 01期

关键词：

D O I：

10.1007/s00253-006-0452-0

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Artemisinin isolated from the aerial parts of Artemisia annua L. is a promising and potent antimalarial drug which has a remarkable activity against chloroquine-resistant and chloroquine-sensitive strains of Plasmodium falciparum, and is useful in treatment of cerebral malaria. Because the low content (0.01-1 %) of artemisinin in A. annua is a limitation to the commercial production of the drug, many research groups have been focusing their researches on enhancing the production of artemisinin in tissue culture or in the whole plant of A. annua. This review mainly focuses on the progresses made in the production of artemisinin from A. annua by biotechnological strategies including in vitro tissue culture, metabolic regulation of artemisinin biosynthesis, genetic engineering, and bioreactor technology.

引用

页码：11 / 20

页数：10

共 105 条

[1] Artemisinin, a novel antimalarial drug: Biochemical and molecular approaches for enhanced production [J].

Abdin, MZ ;

Israr, M ;

Rehman, RU ;

Jain, SK .

PLANTA MEDICA, 2003, 69 (04) :289-299

[2]

Aitkens-Christie J., 1995, AUTOMATION ENV CONTR, P1, DOI DOI 10.1007/978-94-015-8461-6

[3] BIOSYNTHESIS OF ARTEMISININ IN ARTEMISIA-ANNUA [J].

AKHILA, A ;

THAKUR, RS ;

POPLI, SP .

PHYTOCHEMISTRY, 1987, 26 (07) :1927-1930

[4] CYTOKININ AUXIN BALANCE IN CROWN GALL TUMORS IS REGULATED BY SPECIFIC LOCI IN THE T-DNA [J].

AKIYOSHI, DE ;

MORRIS, RO ;

HINZ, R ;

MISCHKE, BS ;

KOSUGE, T ;

GARFINKEL, DJ ;

GORDON, MP ;

NESTER, EW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (02) :407-411

[5] T-DNA OF AGROBACTERIUM-TUMEFACIENS ENCODES AN ENZYME OF CYTOKININ BIOSYNTHESIS [J].

AKIYOSHI, DE ;

KLEE, H ;

AMASINO, RM ;

NESTER, EW ;

GORDON, MP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (19) :5994-5998

[6]

[Anonymous], 1979, CHINESE MED J-PEKING, V92, P811

[7] A CDNA-ENCODING FARNESYL PYROPHOSPHATE SYNTHASE IN WHITE LUPIN [J].

ATTUCCI, S ;

AITKEN, SM ;

IBRAHIM, RK ;

GULICK, PJ .

PLANT PHYSIOLOGY, 1995, 108 (02) :835-836

[8] Metabolic engineering of isoprenoids [J].

Barkovich, R ;

Liao, JC .

METABOLIC ENGINEERING, 2001, 3 (01) :27-39

[9] The future of antimalarials:: artemisinins and synthetic endoperoxides [J].

Bégué, JP ;

Bonnet-Delpon, D .

DRUGS OF THE FUTURE, 2005, 30 (05) :509-518

[10] Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua [J].

Bertea, CM ;

Freije, JR ;

van der Woude, H ;

Verstappen, FWA ;

Perk, L ;

Marquez, V ;

De Kraker, JW ;

Posthumus, MA ;

Jansen, BJM ;

de Groot, A ;

Franssen, MCR ;

Bouwmeester, HJ .

PLANTA MEDICA, 2005, 71 (01) :40-47

← 1 2 3 4 5 6 7 8 9 10 →