The role of miR-150 in normal and malignant hematopoiesis

被引：101
作者：
He, Y. [1 ]
Jiang, X. [1 ,2 ]
Chen, J. [1 ,2 ]
机构：
[1] Univ Chicago, Comm Canc Biol, Chicago, IL 60637 USA
[2] Univ Chicago, Dept Med, Hematol Oncol Sect, Chicago, IL 60637 USA
来源：
ONCOGENE | 2014年 / 33卷 / 30期
基金：
美国国家卫生研究院;
关键词：
miR-150; hematopoiesis; hematopoietic malignancies; expression profiles; gene regulation; target genes; B-CELL DEVELOPMENT; C-MYB; MICRORNA EXPRESSION; MEDIATED CONTROL; MLL; LEUKEMIA; IDENTIFICATION; LYMPHOMA; LINEAGE; DIFFERENTIATION;
D O I：
10.1038/onc.2013.346
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs are a class of small non-coding RNAs that have been implicated to mediate gene regulation in virtually all important biological processes. Recently there is accumulating evidence showing that miR-150 has essential regulatory roles in both normal and malignant hematopoiesis and holds great potential as a therapeutic target in treating various types of hematopoietic malignancies. The purpose of this review is to summarize our current knowledge about the expression patterns, biological functions and regulatory mechanisms of miR-150 in normal and malignant hematopoiesis, and to highlight the important questions to be answered in this burgeoning field.
引用
收藏
页码：3887 / 3893
页数：7
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