Synthesis of novel indolo[2,3-c]quinolinones via Ugi-4CR/palladium-catalyzed arylation

被引：21

作者：

Rasouli, Mohammad Ali ^{[1
]}

Mahdavi, Mohammad ^{[2
]}

Firoozpour, Loghman ^{[3
]}

Shafiee, Abbas ^{[2
]}

Foroumadi, Alireza ^{[2
,3
]}

机构：

[1] Univ Tehran, Univ Coll Sci, Sch Chem, Tehran, Iran

[2] Univ Tehran Med Sci, Fac Pharm & Pharmaceut Sci, Dept Med Chem, Res Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Drug Design & Dev Res Ctr, Tehran, Iran

来源：

TETRAHEDRON | 2014年 / 70卷 / 25期

基金：

美国国家科学基金会;

关键词：

Indolo[2,3-c]quinolinone; Ugi reactions; Pd-catalyzed; Heterocycles; IN-VITRO; ALKALOIDS; NEOCRYPTOLEPINE; HYDROCHLORIDE; CRYPTOLEPINE;

D O I：

10.1016/j.tet.2014.03.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this letter, an expedient method was developed for the construction of novel indolo[2,3-c]quinolinone derivatives via palladium-catalyzed arylation of Ugi adducts obtained from the reaction of indole-2-carboxylic acid, various aromatic aldehydes, 2-bromoanilines, and isocyanides. The reaction proceeded efficiently with various starting materials to produce the indoloquinolinone scaffolds in good yields. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：3931 / 3934

页数：4

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