Exosomal long non-coding RNAs: biological properties and therapeutic potential in cancer treatment

被引：13
作者：
Luo, Jie [1 ]
Xiong, Yan [2 ]
Fu, Pei-fen [3 ]
Li, En-chun [1 ]
Qu, Lei [4 ]
Fan, Xiao [4 ]
Cai, Zhi-jian [5 ,6 ]
Lin, Ai-fu [3 ,4 ]
机构：
[1] Zhejiang Univ, Sch Med, Womens Hosp, Dept Gynecol, Hangzhou 310006, Zhejiang, Peoples R China
[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthoped Surg, Hangzhou 310009, Zhejiang, Peoples R China
[3] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Breast Ctr, Hangzhou 310003, Zhejiang, Peoples R China
[4] Zhejiang Univ, Coll Life Sci, MOE Lab Biosyst Homeostasis & Protect, Hangzhou 310058, Zhejiang, Peoples R China
[5] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Inst Immunol, Hangzhou 310058, Zhejiang, Peoples R China
[6] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Orthopaed, Hangzhou 310058, Zhejiang, Peoples R China
来源：
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B | 2019年 / 20卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Exosome; Long non-coding RNA (lncRNA); Biosynthesis; Biomarker; Drug resistance; PROGNOSTIC BIOMARKER; MEDIATED TRANSFER; BIOGENESIS; MECHANISM;
D O I：
10.1631/jzus.B1900039
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Exosomes and long non-coding RNAs (lncRNAs) are emerging as important elements contributing to a more comprehensive understanding of cancer development and progression. The discovery of lncRNAs in exosomes further indicates their bona fide biological functional roles in cancer development and drug resistance. In this review, we describe the biogenesis of exosomes and summarize the function of exosomal lncRNAs in the field of cancer research. These findings strikingly advance current knowledge of exosomal lncRNAs and suggest that they may be promising diagnostic biomarkers and therapeutic targets for cancer.
引用
收藏
页码：488 / 495
页数：8
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