Carapanolides J-L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production

被引：26

作者：

Matsui, Yuuki ^{[1
]}

Kikuchi, Takashi ^{[1
]}

Inoue, Takanobu ^{[1
]}

Muraoka, Osamu ^{[2
]}

Yamada, Takeshi ^{[1
]}

Tanaka, Reiko ^{[1
]}

机构：

[1] Osaka Univ Pharmaceut Sci, Med Chem Lab, Takatsuki, Osaka 5691094, Japan

[2] Kinki Univ, Fac Pharmaceut Sci, Higashiosaka, Osaka 5778502, Japan

来源：

MOLECULES | 2014年 / 19卷 / 11期

关键词：

Carapa guianensis; andiroba; seeds; gedunin; phragmalin; limonoids; NO production; IN-VITRO; LIMONOIDS; AUBLET;

D O I：

10.3390/molecules191117130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel gedunin and two novel phragmalin-type limonoids, named carapanolides J-L (compounds 1-3) as well as a known gedunin-type limonoid 4 were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D and 2D NMR spectroscopy and HRFABMS. Compounds 1-4 were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages.

引用

页码：17130 / 17140

页数：11

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