Probiotics, Prebiotics, Synbiotics, and Paraprobiotics as a Therapeutic Alternative for Intestinal Mucositis

被引：54

作者：

Batista, Viviane Lima ^{[1
]}

da Silva, Tales Fernando ^{[1
]}

de Jesus, Luis Claudio Lima ^{[1
]}

Coelho-Rocha, Nina Dias ^{[1
]}

Barroso, Fernanda Alvarenga Lima ^{[1
]}

Tavares, Laisa Macedo ^{[1
]}

Azevedo, Vasco ^{[1
]}

Mancha-Agresti, Pamela ^{[1
,2
]}

Drumond, Mariana Martins ^{[1
,3
]}

机构：

[1] Univ Fed Minas Gerais UFMG, Inst Ciencias Biol, Dept Biol Geral, Lab Genet Celular Mol LGCM, Belo Horizonte, MG, Brazil

[2] FAMINAS BH, Fac Minas, Belo Horizonte, MG, Brazil

[3] Ctr Fed Educ Tecnol Minas Gerais CEFET MG, Dept Ciencias Biol, Belo Horizonte, MG, Brazil

来源：

FRONTIERS IN MICROBIOLOGY | 2020年 / 11卷

关键词：

lactic acid bacteria; chemotherapy; intestinal inflammation; treatment; mucosite; LACTOBACILLUS-RHAMNOSUS GG; LACTIC-ACID BACTERIA; INFLAMMATORY-BOWEL-DISEASE; COLORECTAL-CANCER; GUT MICROBIOTA; FRUCTO-OLIGOSACCHARIDES; SALMONELLA-TYPHIMURIUM; GROWTH-PERFORMANCE; GENE-EXPRESSION; 5-FLUOROURACIL;

D O I：

10.3389/fmicb.2020.544490

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Intestinal mucositis, a cytotoxic side effect of the antineoplastic drug 5-fluorouracil (5-FU), is characterized by ulceration, inflammation, diarrhea, and intense abdominal pain, making it an important issue for clinical medicine. Given the seriousness of the problem, therapeutic alternatives have been sought as a means to ameliorate, prevent, and treat this condition. Among the alternatives available to address this side effect of treatment with 5-FU, the most promising has been the use of probiotics, prebiotics, synbiotics, and paraprobiotics. This review addresses the administration of these "biotics" as a therapeutic alternative for intestinal mucositis caused by 5-FU. It describes the effects and benefits related to their use as well as their potential for patient care.

引用

页数：17

共 152 条

[1] Milk fermented by Lactobacillus species from Brazilian artisanal cheese protect germ-free-mice against Salmonella Typhimurium infection [J].