Interrogating open issues in cancer precision medicine with patient-derived xenografts

被引：543

作者：

Byrne, Annette T. ^{[1
]}

Alferez, Denis G. ^{[2
]}

Amant, Frederic ^{[3
,4
]}

Annibali, Daniela ^{[3
,5
]}

Arribas, Joaquin ^{[5
,6
,7
,8
]}

Biankin, Andrew V. ^{[9
]}

Bruna, Alejandra ^{[10
]}

Budinska, Eva ^{[11
,12
]}

Caldas, Carlos ^{[10
]}

Chang, David K. ^{[9
]}

Clarke, Robert B. ^{[2
]}

Clevers, Hans ^{[13
,14
]}

Coukos, George ^{[15
]}

Dangles-Marie, Virginie ^{[16
,17
]}

Eckhardt, S. Gail ^{[18
]}

Gonzalez-Suarez, Eva ^{[19
]}

Hermans, Els ^{[3
,5
]}

Hidalgo, Manuel ^{[20
,21
]}

Jarzabek, Monika A. ^{[1
]}

de Jong, Steven ^{[22
]}

Jonkers, Jos ^{[23
]}

Kemper, Kristel ^{[23
]}

Lanfrancone, Luisa ^{[24
]}

Maelandsmo, Gunhild Mari ^{[25
]}

Marangoni, Elisabetta ^{[26
]}

Marine, Jean-Christophe ^{[27
,28
]}

Medico, Enzo ^{[29
,30
]}

Norum, Jens Henrik ^{[25
]}

Palmer, Hector G. ^{[31
,32
]}

Peeper, Daniel S. ^{[23
]}

Pelicci, Pier Giuseppe ^{[24
]}

Piris-Gimenez, Alejandro ^{[31
,32
]}

Roman-Roman, Sergio ^{[26
]}

Rueda, Oscar M. ^{[10
]}

Seoane, Joan ^{[6
,7
,8
]}

Serra, Violeta ^{[31
,32
]}

Soucek, Laura ^{[6
,7
]}

Vanhecke, Dominique ^{[15
]}

Villanueva, Alberto ^{[33
,34
]}

Vinolo, Emilie ^{[35
]}

Bertotti, Andrea ^{[29
,30
]}

Trusolino, Livio ^{[29
,30
]}

机构：

[1] Royal Coll Surgeons Ireland, Dublin 2, Ireland

[2] Univ Manchester, Manchester Canc Res Ctr, Div Mol & Clin Canc Sci, Breast Canc Now Res Unit, Manchester M20 4QL, Lancs, England

[3] Katholieke Univ Leuven, B-3000 Louvain, Belgium

[4] Netherlands Canc Inst, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

[5] Vall Hebron Inst Oncol, Barcelona 08035, Spain

[6] Univ Autonoma Barcelona, Bellaterra 08193, Spain

[7] Inst Catalana Rec & Estud Avancats, Barcelona 08010, Spain

[8] CIBERONC, Barcelona 08035, Spain

[9] Univ Glasgow, Inst Canc Sci, Wolfson Wohl Canc Res Ctr, Glasgow G61 1QH, Lanark, Scotland

[10] Univ Cambridge, Cambridge Canc Ctr, Canc Res UK Cambridge Inst, Cambridge CB2 0RE, England

[11] Masarykova Univ, Fac Sci, Fac Med, Inst Biostat & Anal, Brno 62500, Czech Republic

[12] Masarykova Univ, Res Ctr Tox Cpds Environm, Brno 62500, Czech Republic

[13] Univ Med Ctr Utrecht, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands

[14] Princess Maxima Ctr Pediat Oncol, NL-3584 CT Utrecht, Netherlands

[15] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Lausanne, Switzerland

[16] PSL Res Univ, Inst Curie, Translat Res Dept, F-75005 Paris, France

[17] Univ Paris 05, Sorbonne Paris Cite, Fac Pharm Paris, F-75006 Paris, France

[18] Univ Colorado, Ctr Canc, Aurora, CO 80045 USA

[19] Hosp Llobregat, Bellvitge Biomed Res Inst IDIBELL, Canc Epigenet & Biol Program, Barcelona 08908, Spain

[20] Beth Israel Deaconess Med Ctr, Boston, MA USA

[21] Harvard Med Sch, Boston, MA 02215 USA

[22] Univ Groningen, Univ Med Ctr Groningen, NL-9713GZ Groningen, Netherlands

[23] Netherlands Canc Inst, EurOPDX Consortium, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands

[24] European Inst Oncol, Dept Expt Oncol, I-20139 Milan, Italy

[25] Oslo Univ Hosp, Inst Canc Res, N-0424 Oslo, Norway

[26] PSL Res Univ, Translat Res Dept, F-75005 Paris, France

[27] Katholieke Univ Leuven, Dept Oncol, Lab Mol Canc Biol, B-3000 Louvain, Belgium

[28] VIB, Ctr Canc Biol, B-3000 Louvain, Belgium

[29] Univ Torino, Candiolo Canc Inst IRCCS, I-10060 Candiolo, Torino, Italy

[30] Univ Torino, Dept Oncol, I-10060 Candiolo, Torino, Italy

[31] Vall Hebron Inst Oncol, Barcelona 08035, Spain

[32] CIBERONC, Barcelona 08035, Spain

[33] Hosp Llobregat, Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol ICO, Program Canc Therapeut Resistance ProCURE, Barcelona 08098, Spain

[34] Hosp Llobregat, Business Bioincubator, Xenopat SL, Bellvitge Hlth Sci Campus, Barcelona 08907, Spain

[35] Seeding Sci SAS, F-75020 Paris, France

来源：

NATURE REVIEWS CANCER | 2017年 / 17卷 / 04期

基金：

爱尔兰科学基金会; 欧洲研究理事会; 英国惠康基金;

关键词：

CIRCULATING TUMOR-CELLS; BREAST-CANCER; STEM-CELL; ACQUIRED-RESISTANCE; GENE-EXPRESSION; PHASE-II; COLON-CANCER; MOUSE MODEL; INTRINSIC RESISTANCE; MELANOMA PATIENT;

D O I：

10.1038/nrc.2016.140

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective ofEurOPDX, an international initiative devoted to PDX-based research.

引用

页码：254 / 268

页数：15

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