The transcriptional landscape of polyploid wheat

被引：704

作者：

Ramirez-Gonzalez, R. H. ^{[1
]}

Borrill, P. ^{[1
]}

Lang, D. ^{[2
]}

Harrington, S. A. ^{[1
]}

Brinton, J. ^{[1
]}

Venturini, L. ^{[3
]}

Davey, M. ^{[4
]}

Jacobs, J. ^{[4
]}

van Ex, F. ^{[4
]}

Pasha, A. ^{[5
]}

Khedikar, Y. ^{[6
]}

Robinson, S. J. ^{[6
]}

Cory, A. T. ^{[7
]}

Florio, T. ^{[1
]}

Concia, L. ^{[8
]}

Juery, C. ^{[9
]}

Schoonbeek, H. ^{[1
]}

Steuernagel, B. ^{[1
]}

Xiang, D. ^{[10
]}

Ridout, C. J. ^{[1
]}

Chalhoub, B. ^{[11
]}

Mayer, K. F. X. ^{[2
,12
]}

Benhamed, M. ^{[8
]}

Latrasse, D. ^{[8
]}

Bendahmane, A. ^{[8
]}

Wulff, B. B. H. ^{[1
]}

Appels, R. ^{[14
,15
]}

Tiwari, V. ^{[16
]}

Datla, R. ^{[10
]}

Choulet, F. ^{[9
]}

Pozniak, C. J. ^{[7
]}

Provart, N. J. ^{[5
]}

Sharpe, A. G. ^{[17
]}

Paux, E. ^{[9
]}

Spannagl, M. ^{[2
]}

Braeutigam, A. ^{[18
,19
]}

Uauy, C. ^{[1
]}

机构：

[1] John Innes Ctr, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England

[2] Helmholtz Ctr Munich, Plant Genome & Syst Biol, Ingolstaedter Landstr 1, D-85764 Neuherberg, Germany

[3] Earlham Inst, Norwich Res Pk, Norwich NR4 7UZ, Norfolk, England

[4] Bayer Crop Sci, Innovat Ctr, Technol Pk 38, B-9052 Zwijnaarde, Belgium

[5] Univ Toronto, Dept Cell & Syst Biol, Ctr Anal Genome Evolut & Funct, 25 Willcocks St, Toronto, ON M5S 3B2, Canada

[6] Agr & Agri Food Canada, Saskatoon Res & Dev Ctr, 107 Sci Pl, Saskatoon, SK S7N 0X2, Canada

[7] Univ Saskatchewan, Crop Dev Ctr, Agr Bldg,51 Campus Dr, Saskatoon, SK S7N 5A8, Canada

[8] Univ Paris Diderot, Univ Paris Saclay,Univ Paris Sud, Univ Evry,CNRS,INRA,Sorbonne Paris Cite, Inst Plant Sci Paris Saclay IPS2,UMR 9213,UMR1403, Batiment 630, F-91405 Orsay, France

[9] UCA, INRA, GDEC, 5 Chemin Beaulieu, F-63039 Clermont Ferrand, France

[10] Natl Res Council Canada, Aquat & Crop Resource Dev, 110 Gymnasium Pl, Saskatoon, SK S7N 0W9, Canada

[11] INRA, 2 Rue Gaston Cremieux, F-9057 Evry, France

[12] Tech Univ Munich, Sch Life Sci Weihenstephan, Munich, Germany

[13] IWGSC, 5207 Wyoming Rd, Bethesda, MD 20816 USA

[14] La Trobe Univ, AgriBio, Univ Melbourne, Sch BioSci, 90 South St, Perth, WA 6150, Australia

[15] Murdoch Univ, Sch Vet & Life Sci, 90 South St, Perth, WA 6150, Australia

[16] Univ Maryland, Plant Sci & Landscape Architecture, 4291 Field House Dr, College Pk, MD 20742 USA

[17] Univ Saskatchewan, Global Inst Food Secur, 110 Gymnasium Pl, Saskatoon, SK S7N 4J8, Canada

[18] IPK Gatersleben, Mol Genet, Corrensstr 3, D-06466 Gatersleben, Germany

[19] Univ Bielefeld, Fac Biol, Inst Computat Biol, D-33501 Bielefeld, Germany

来源：

SCIENCE | 2018年 / 361卷 / 6403期

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会;

关键词：

GENE-EXPRESSION; DNA; METHYLATION; EVOLUTION; DUPLICATION; RESISTANCE; DOMINANCE; NETWORKS; GENOMES; HSFB2B;

D O I：

10.1126/science.aar6089

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The coordinated expression of highly related homoeologous genes in polyploid species underlies the phenotypes of many of the world's major crops. Here we combine extensive gene expression datasets to produce a comprehensive, genome-wide analysis of homoeolog expression patterns in hexaploid bread wheat. Bias in homoeolog expression varies between tissues, with similar to 30% of wheat homoeologs showing nonbalanced expression. We found expression asymmetries along wheat chromosomes, with homoeologs showing the largest inter-tissue, inter-cultivar, and coding sequence variation, most often located in high-recombination distal ends of chromosomes. These transcriptionally dynamic genes potentially represent the first steps toward neo- or subfunctionalization of wheat homoeologs. Coexpression networks reveal extensive coordination of homoeologs throughout development and, alongside a detailed expression atlas, provide a framework to target candidate genes underpinning agronomic traits in wheat.

引用

页码：662 / +

页数：13

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