Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

被引：36
作者：
Brandi, Maria Luisa [1 ]
Giustina, Andrea [2 ,3 ]
机构：
[1] Univ Florence, Dept Biomed Expt & Clin Sci, Florence, Italy
[2] San Raffaele Vita Salute Univ, Inst Endocrine & Metab Sci, Milan, Italy
[3] IRCS San Raffaele Hosp, Div Endocrinol, Milan, Italy
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2020年 / 31卷 / 12期
关键词：
ACUTE RESPIRATORY SYNDROME; ESTROGEN-RECEPTOR-ALPHA; NITRIC-OXIDE; POSTMENOPAUSAL WOMEN; VITAMIN-D; DISEASE; HORMONES; RISK; HYPOGONADISM; TESTOSTERONE;
D O I：
10.1016/j.tem.2020.09.003
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sexspecific management the disease.
引用
收藏
页码：918 / 927
页数：10
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