α-Arylation/Heteroarylation of Chiral α-Aminomethyltrifluoroborates by Synergistic Iridium Photoredox/Nickel Cross-Coupling Catalysis

被引：122
作者：
El Khatib, Mirna [1 ]
Massarico Serafim, Ricardo Augusto [1 ,2 ]
Molander, Gary A. [1 ]
机构：
[1] Univ Penn, Roy & Diana Vagelos Labs, Dept Chem, Philadelphia, PA 19104 USA
[2] Univ Sao Paulo, FCF USP, Fac Pharmaceut Sci, Dept Pharm, BR-05508 Sao Paulo, Brazil
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 01期
关键词：
amino acids; cross-coupling; heterocycles; nickel; photochemistry; BOC-PROTECTED AMINOMETHYLTRIFLUOROBORATE; SINGLE-ELECTRON TRANSMETALATION; LIGHT-MEDIATED ADDITION; AMINO-ACIDS; CARBOXYLIC-ACIDS; ASYMMETRIC-SYNTHESIS; CONJUGATE ADDITIONS; RADICALS; SECONDARY; ARYL;
D O I：
10.1002/anie.201506147
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Direct access to complex, enantiopure benzylamine architectures using a synergistic iridium photoredox/nickel cross-coupling dual catalysis strategy has been developed. New C(sp(3)) C(sp(2)) bonds are forged starting from abundant and inexpensive natural amino acids.
引用
收藏
页码：254 / 258
页数：5
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