Bioactive constituents from the leaves of Croton tiglium

被引：4
作者：
Jiang, Zhi-Yong [1 ,2 ,3 ,4 ]
Duan, Li-Kun [2 ,3 ]
Feng, Jin-E [2 ,3 ]
Liu, Chun-Jiang [1 ]
Li, Xiao-Fei [1 ]
Li, Yuan [1 ]
Huang, Chun-Qiu [5 ]
Shi, Sheng-Li [6 ]
Zuo, Ai-Xue [1 ]
He, Hong-Ping [1 ]
机构：
[1] Yunnan Univ Chinese Med, Sch Ethn Med, Kunming 650500, Yunnan, Peoples R China
[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China
[3] Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China
[4] Yunnan Univ Chinese Med, Key Lab Modern Res Ethn Med Coll Yunnan Prov, Kunming 650500, Yunnan, Peoples R China
[5] Yunnan Phytopharmaceut Co Ltd, Kunming 650505, Yunnan, Peoples R China
[6] Yuxi Normal Univ, Sch Chem Biol & Environm, Yuxi 653100, Yunnan, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2022年 / 49卷
基金：
中国国家自然科学基金;
关键词：
Croton tiglium; Phorbol esters; Sesquiterpenoids; Larvicidal activity; a-glucosidase inhibitory activity; CYTOTOXIC PHORBOL ESTERS; DITERPENOIDS; SEEDS; SESQUITERPENES;
D O I：
10.1016/j.phytol.2022.03.003
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Fifteen compounds, including five new phorbol esters (1-5) and ten known metabolites were isolated from the leaves of Croton tiglium. The structures of new compounds 1-5 were determined by comprehensive analysis of the HRESIMS, IR, 1D and 2D NMR spectral data. The isolates were assayed for their larvicidal and alpha-glucosidase inhibitory activity; results suggested the new compounds 1-4 possessed significant insecticidal activity, inhibiting the Plutella xylostella with LC50 values ranging from 0.081 to 0.114 mu g/mL, while the sesquiterpenoids 11 and 15 showed noticeable alpha-glucosidase inhibitory activity with IC50 values of 11.27 and 8.13 mu M, respectively.
引用
收藏
页码：65 / 72
页数：8
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