Bioactive constituents from the leaves of Croton tiglium

被引：4
|
作者：
Jiang, Zhi-Yong [1 ,2 ,3 ,4 ]
Duan, Li-Kun [2 ,3 ]
Feng, Jin-E [2 ,3 ]
Liu, Chun-Jiang [1 ]
Li, Xiao-Fei [1 ]
Li, Yuan [1 ]
Huang, Chun-Qiu [5 ]
Shi, Sheng-Li [6 ]
Zuo, Ai-Xue [1 ]
He, Hong-Ping [1 ]
机构：
[1] Yunnan Univ Chinese Med, Sch Ethn Med, Kunming 650500, Yunnan, Peoples R China
[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China
[3] Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China
[4] Yunnan Univ Chinese Med, Key Lab Modern Res Ethn Med Coll Yunnan Prov, Kunming 650500, Yunnan, Peoples R China
[5] Yunnan Phytopharmaceut Co Ltd, Kunming 650505, Yunnan, Peoples R China
[6] Yuxi Normal Univ, Sch Chem Biol & Environm, Yuxi 653100, Yunnan, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2022年 / 49卷
基金：
中国国家自然科学基金;
关键词：
Croton tiglium; Phorbol esters; Sesquiterpenoids; Larvicidal activity; a-glucosidase inhibitory activity; CYTOTOXIC PHORBOL ESTERS; DITERPENOIDS; SEEDS; SESQUITERPENES;
D O I：
10.1016/j.phytol.2022.03.003
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Fifteen compounds, including five new phorbol esters (1-5) and ten known metabolites were isolated from the leaves of Croton tiglium. The structures of new compounds 1-5 were determined by comprehensive analysis of the HRESIMS, IR, 1D and 2D NMR spectral data. The isolates were assayed for their larvicidal and alpha-glucosidase inhibitory activity; results suggested the new compounds 1-4 possessed significant insecticidal activity, inhibiting the Plutella xylostella with LC50 values ranging from 0.081 to 0.114 mu g/mL, while the sesquiterpenoids 11 and 15 showed noticeable alpha-glucosidase inhibitory activity with IC50 values of 11.27 and 8.13 mu M, respectively.
引用
收藏
页码：65 / 72
页数：8
相关论文
共 50 条
  • [21] High Quality de Novo Transcriptome Assembly of Croton tiglium
    Haak, Markus
    Vinke, Svenja
    Keller, Willy
    Droste, Julian
    Rueckert, Christian
    Kalinowski, Joern
    Pucker, Boas
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2018, 5
  • [22] Activity-guided Isolation of a Novel Protein from Croton tiglium with Antifungal and Antibacterial Activities
    Shahid, Muhammad
    Tayyab, Muhammad
    Naz, Farah
    Jamil, Amer
    Ashraf, Muhammad
    Gilani, Anwarul Hassan
    PHYTOTHERAPY RESEARCH, 2008, 22 (12) : 1646 - 1649
  • [23] Bioactive Indole Alkaloids from Croton echioides
    Novello, Claudio R.
    Marques, Luis C.
    Pires, Murilo E.
    Kutschenco, Ana P.
    Nakamura, CelsoV.
    Nocchi, Samara
    Sarragiotto, Maria H.
    Mello, Joao C. P.
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2016, 27 (12) : 2203 - 2209
  • [24] Evaluation of the purification process of Croton tiglium L. seeds by chromatographic methods
    Mundengara Deepak
    P. Divya
    Cheruthazhakkat Sulaiman
    Balachandran Indira
    JPC – Journal of Planar Chromatography – Modern TLC, 2021, 34 : 345 - 351
  • [25] Botany, traditional uses, phytochemistry, pharmacological and toxicological effects of Croton tiglium Linn.: a comprehensive review
    Zhang, Ting
    Liu, Zibo
    Sun, Xue
    Liu, Ziqi
    Zhang, Lilin
    Zhang, Qing
    Peng, Wei
    Wu, Chunjie
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2022, 74 (08) : 1061 - 1084
  • [26] CHEMICAL CONSTITUENTS OF A POPULATION OF Croton gratissimus (EUPHORBIACEAE)
    Canelo, Laura I. N.
    Mafuca, Isabel
    Mata, Rosalina S.
    Mendonca, Dina I.
    QUIMICA NOVA, 2017, 40 (09): : 1035 - 1038
  • [27] Chemical Profile of the Volatile Constituents and Antimicrobial Activity of the Essential Oils from Croton adipatus, Croton thurifer, and Croton collinus
    Leslie Cucho-Medrano, Juana Liz
    Mendoza-Beingolea, Sammy Wesley
    Fuertes-Ruiton, Cesar Maximo
    Salazar-Salvatierra, Maria Elena
    Herrera-Calderon, Oscar
    ANTIBIOTICS-BASEL, 2021, 10 (11):
  • [28] Croton Tiglium Extract Induces the Apoptosis in Human Lung Cancer A549 Cells
    Li, Changyou
    Wu, Xiao
    Sun, Rongli
    Zhao, Peng
    Liu, Fengjuan
    Zhang, Chunling
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S1532 - S1532
  • [29] Evaluation of acute toxicity and intestinal transit time of Croton tiglium L. seeds
    Vekariya, Shweta
    Taviad, Krushnkumar
    Ranpariya, Nidhi
    Nariya, Mukesh
    Acharya, R. N.
    INDIAN JOURNAL OF NATURAL PRODUCTS AND RESOURCES, 2018, 9 (04): : 331 - 335
  • [30] Chemical constituents from the roots of Croton crassifolius and their chemophenetic significance
    Li, Jia-Yi
    Bai, Ming
    Song, Shao-Jiang
    Huang, Xiao-Xiao
    BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2023, 107
12345