Bioactive constituents from the leaves of Croton tiglium

被引：4

作者：

Jiang, Zhi-Yong ^{[1
,2
,3
,4
]}

Duan, Li-Kun ^{[2
,3
]}

Feng, Jin-E ^{[2
,3
]}

Liu, Chun-Jiang ^{[1
]}

Li, Xiao-Fei ^{[1
]}

Li, Yuan ^{[1
]}

Huang, Chun-Qiu ^{[5
]}

Shi, Sheng-Li ^{[6
]}

Zuo, Ai-Xue ^{[1
]}

He, Hong-Ping ^{[1
]}

机构：

[1] Yunnan Univ Chinese Med, Sch Ethn Med, Kunming 650500, Yunnan, Peoples R China

[2] Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Yunnan, Peoples R China

[3] Yunnan Minzu Univ, Minist Educ, Kunming 650500, Yunnan, Peoples R China

[4] Yunnan Univ Chinese Med, Key Lab Modern Res Ethn Med Coll Yunnan Prov, Kunming 650500, Yunnan, Peoples R China

[5] Yunnan Phytopharmaceut Co Ltd, Kunming 650505, Yunnan, Peoples R China

[6] Yuxi Normal Univ, Sch Chem Biol & Environm, Yuxi 653100, Yunnan, Peoples R China

来源：

PHYTOCHEMISTRY LETTERS | 2022年 / 49卷

基金：

中国国家自然科学基金;

关键词：

Croton tiglium; Phorbol esters; Sesquiterpenoids; Larvicidal activity; a-glucosidase inhibitory activity; CYTOTOXIC PHORBOL ESTERS; DITERPENOIDS; SEEDS; SESQUITERPENES;

D O I：

10.1016/j.phytol.2022.03.003

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Fifteen compounds, including five new phorbol esters (1-5) and ten known metabolites were isolated from the leaves of Croton tiglium. The structures of new compounds 1-5 were determined by comprehensive analysis of the HRESIMS, IR, 1D and 2D NMR spectral data. The isolates were assayed for their larvicidal and alpha-glucosidase inhibitory activity; results suggested the new compounds 1-4 possessed significant insecticidal activity, inhibiting the Plutella xylostella with LC50 values ranging from 0.081 to 0.114 mu g/mL, while the sesquiterpenoids 11 and 15 showed noticeable alpha-glucosidase inhibitory activity with IC50 values of 11.27 and 8.13 mu M, respectively.

引用

页码：65 / 72

页数：8

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