Apatinib, combined with chemotherapy or alone is effective in treating angiosarcoma: a case report

被引：2

作者：

Liu, Mingyang ^{[1
]}

Liu, Yongmin ^{[1
]}

Guo, Huannan ^{[1
]}

Fu, Dongwei ^{[1
]}

Lv, Lili ^{[1
]}

Chen, Chunhong ^{[1
]}

Li, Yanlin ^{[2
]}

Zhang, Wenqian ^{[2
]}

Yao, Ming ^{[2
]}

Zhao, Limin ^{[1
]}

机构：

[1] Heilongjiang Prov Land Reclamat Bur, Gen Hosp, Dept Oncol, 235 Hashuang Rd, Harbin 150088, Heilongjiang, Peoples R China

[2] OrigiMed, Shanghai, Peoples R China

来源：

ANTI-CANCER DRUGS | 2019年 / 30卷 / 07期

关键词：

angiosarcoma; apatinib; vascular endothelial growth factor receptor; EPITHELIOID HEMANGIOENDOTHELIOMA; SOFT-TISSUE; SIROLIMUS; SARCOMA;

D O I：

10.1097/CAD.0000000000000738

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Angiosarcomas are rare but aggressive tumors with poor prognosis. The treatment of angiosarcomas with vascular endothelial growth factor receptor inhibitors is still in the stage of clinical exploration. Herein we reported a patient of skin angiosarcoma with multiple organ metastasis. She was resistance to multiline chemotherapy and pazopanib but achieved remarkable shrinkage of the lesion after apatinib treatment combined with chemotherapy or alone. The progression-free survival of the primary lesion with KRAS V14I and RBM10 E119D mutations (10 months) was shorter than that of the brain without the mutation (>= 12 months). Although it is not clear whether the KRAS V14I and RBM10 E119D mutations are the main factors that impact the effect of apatinib treatment or not, the results of this study will provide valuable clues for relevant follow-up basic and clinical studies. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：762 / 765

页数：4

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