Nabscessins A and B, Aminocyclitol Derivatives from Nocardia abscessus IFM 10029T

被引：31

作者：

Hara, Shoko ^{[1
]}

Ishikawa, Naoki ^{[1
]}

Hara, Yasumasa ^{[1
]}

Nehira, Tatsuo ^{[2
]}

Sakai, Kanae ^{[3
]}

Gonoi, Tohru ^{[3
]}

Ishibashi, Masami ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 1-8-1 Inohana, Chiba 2608675, Japan

[2] Hiroshima Univ, Grad Sch Integrated Arts & Sci, 1-7-1 Kagamiyama, Higashihiroshima 7398521, Japan

[3] Chiba Univ, Med Mycol Res Ctr, Chuo Ku, 1-8-1 Inohana, Chiba 2608673, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 02期

基金：

日本学术振兴会;

关键词：

BIOSYNTHESIS; ANTIBIOTICS;

D O I：

10.1021/acs.jnatprod.6b00935

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new aminocyclitol amide derivatives, nabscessins A (1) and B (2), were isolated from the culture broth of a pathogenic actinomycete species, Nocardia abscessus IFM 10029(T). The structures of nabscessins A and B were elucidated by spectral studies, and the compounds showed antifungal activity against Cryptococcus neoformans, with IC50 values of 32 and 16 mu g/mL, respectively.

引用

页码：565 / 568

页数：4

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