Intricate Roles of Mammalian Sirtuins in Defense against Viral Pathogens

被引：55

作者：

Budayeva, Hanna G. ^{[1
]}

Rowland, Elizabeth A. ^{[1
]}

Cristea, Ileana M. ^{[1
]}

机构：

[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 01期

基金：

美国国家科学基金会;

关键词：

METABOLIC PATHWAYS; VIRUS TYPE-1; INFECTION; CELLS;

D O I：

10.1128/JVI.03220-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

For a number of years, sirtuin enzymes have been appreciated as effective "sensors" of the cellular environment to rapidly transmit information to diverse cellular pathways. Much effort was placed into exploring their roles in human cancers and aging. However, a growing body of literature brings these enzymes to the spotlight in the field of virology. Here, we discuss sirtuin functions in the context of viral infection, which provide regulatory points for therapeutic intervention against pathogens.

引用

页码：5 / 8

页数：4