High-density lipoprotein metabolism and progression of atherosclerosis: new insights from the HDL Atherosclerosis Treatment Study

被引：31
作者：
Asztalos, BF [1 ]
机构：
[1] Tufts Univ, Lipid Metab Lab, HNRCA, Boston, MA 02111 USA
来源：
CURRENT OPINION IN CARDIOLOGY | 2004年 / 19卷 / 04期
关键词：
high-density lipoprotein; high-density lipoprotein subspecies; atherosclerosis; anti-atherogenicity;
D O I：
10.1097/01.hco.0000126979.41946.7e
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Purpose of review The purpose of this review is to summarize the current understanding of the potentially antiatherogenic properties of high-density lipoprotein related to its different components. Recent findings Recent findings on the role of the different high-density lipoprotein subspecies in reverse cholesterol transport, inflammation, endothelial dysfunction, and low-density lipoprotein oxidation are covered. Special emphasis is put on the heterogeneity of high-density lipoprotein and functional changes related to specific high-density lipoprotein particles with the potential therapeutic alterations of high-density lipoprotein metabolism. Summary The diverse action of high-density lipoprotein observed could be explained by the heterogeneity of high-density lipoprotein particles with completely different composition and properties. The modification of specific high-density lipoprotein subpopulations to reach the maximum atheroprotective effects under various pathologic conditions bears great potential in lipid research.
引用
收藏
页码：385 / 391
页数：7
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