Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect

被引：19

作者：

Bali, Alka ^{[1
]}

Malhotra, Sarika ^{[2
]}

Dhir, Himjyoti ^{[2
]}

Kumar, Anil ^{[1
]}

Sharma, Ajay ^{[3
]}

机构：

[1] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India

[2] Punjabi Univ, Dept Pharmaceut Sci & Drug Res, Patiala, Punjab, India

[3] Zydus Cadila Ltd, Div Pharmacol, Ahmadabad, Gujarat, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 11期

关键词：

1-(Quinolyloxypropyl)-4-aryl-piperazines; Atypical antipsychotics; Schizophrenia; Similarity; POTENT; DERIVATIVES; AFFINITY; LIGANDS;

D O I：

10.1016/j.bmcl.2009.04.019

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 1-(quinoliloxypropyl)-4-aryl-piperazines has been synthesized and the target compounds evaluated for atypical antipsychotic activity in apomorphine induced mesh climbing and stereotypic behaviour in mice. The 8-hydroxyquinoline ether derivative 14 has emerged as an important lead compound showing a potential atypical antipsychotic profile. Employing appropriate physicochemical properties, the similarity of the compounds was assessed with respect to some atypical antipsychotic drugs as clozapine, ketanserine, ziprasidone and risperidone. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：3041 / 3044

页数：4

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