Structure and Properties Characterization of Amphiphilic Dendrons Modified Lipid Membrane

被引：3

作者：

Han, Jin ^{[1
]}

Iimure, Yosuke ^{[1
]}

Okamoto, Yukihiro ^{[1
]}

Suga, Keishi ^{[2
]}

Umakoshi, Hiroshi ^{[1
]}

机构：

[1] Osaka Univ, Grad Sch Engn Sci, Div Chem Engn, 1-3 Machikaneyama Cho, Osaka, Osaka 5608531, Japan

[2] Tohoku Univ, Grad Sch Engn, Dept Chem Engn, Aoba Ku, 6-6-07 Aoba, Sendai, Miyagi 9808579, Japan

来源：

CHEMISTRY LETTERS | 2021年 / 50卷 / 01期

基金：

日本学术振兴会;

关键词：

Amphiphilic dendrimer; Lipid membrane; Hydration state; DENDRIMERS;

D O I：

10.1246/cl.200633

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Coassembly of lipids and polyamidoamine amphiphilic dendrons (AD) is expected to provide desirable characteristics to drug delivery carriers. However, there have been few studies about structure and properties of these coassemblies. In this study, coassemblies (lipid-AD) were prepared by different generation and composition ratio of AD, and then the structure and their properties were characterized, especially fluidity and hydration state. In conclusion, generation of AD showed significant influence on coassembly structure and hydration state.

引用

页码：187 / 190

页数：4

共 20 条

[1] Liposomal Formulations in Clinical Use: An Updated Review [J].

Bulbake, Upendra ;

Doppalapudi, Sindhu ;

Kommineni, Nagavendra ;

Khan, Wahid .

PHARMACEUTICS, 2017, 9 (02)

[2] Molecular engineering of dendrimer nanovectors for siRNA delivery and gene silencing [J].

Cao, Yu ;

Liu, Xiaoxuan ;

Peng, Ling .

FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING, 2017, 11 (04) :663-675

[3] Mix and Match: Coassembly of Amphiphilic Dendrimers and Phospholipids Creates Robust, Modular, and Controllable Interfaces [J].

Hinman, Samuel S. ;

Ruiz, Charles J. ;

Cao, Yu ;

Ma, Meghann C. ;

Tang, Jingjie ;

Laurini, Erik ;

Posocco, Paola ;

Giorgio, Suzanne ;

Pricl, Sabrina ;

Peng, Ling ;

Cheng, Quan .

ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (01) :1029-1035

[4] SHORT-CHAIN PHOSPHATIDYLCHOLINES AS SUPERIOR DETERGENTS IN SOLUBILIZING MEMBRANE-PROTEINS AND PRESERVING BIOLOGICAL-ACTIVITY [J].

KESSI, J ;

POIREE, JC ;

WEHRLI, E ;

BACHOFEN, R ;

SEMENZA, G ;

HAUSER, H .

BIOCHEMISTRY, 1994, 33 (35) :10825-10836

[5] Water Dynamics in the Hydration Shells of Biomolecules [J].

Laage, Damien ;

Elsaesser, Thomas ;

Hynes, James T. .

CHEMICAL REVIEWS, 2017, 117 (16) :10694-10725

[6] Molecular studies of the gel to liquid-crystalline phase transition for fully hydrated DPPC and DPPE bilayers [J].

Leekumjorn, Sukit ;

Sum, Amadeu K. .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2007, 1768 (02) :354-365

[7] MEMBRANE FLUIDITY AS DETECTED BY DIPHENYLHEXATRIENE PROBES [J].

LENTZ, BR .

CHEMISTRY AND PHYSICS OF LIPIDS, 1989, 50 (3-4) :171-190

[8] Water mediation in protein folding and molecular recognition [J].

Levy, Yaakov ;

Onuchic, Jose N. .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2006, 35 :389-415

[9] Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics [J].

Liu, Xiaoxuan ;

Liu, Cheng ;

Catapano, Carlo V. ;

Peng, Ling ;

Zhou, Jiehua ;

Rocchi, Palma .

BIOTECHNOLOGY ADVANCES, 2014, 32 (04) :844-852

[10] Self-Assembly of Amphiphilic Dendrimers: The Role of Generation and Alkyl Chain Length in siRNA Interaction [J].

Marquez-Miranda, Valeria ;

Araya-Duran, Ingrid ;

Belen Camarada, Maria ;

Comer, Jeffrey ;

Valencia-Gallegos, Jesus A. ;

Danilo Gonzalez-Nilo, Fernando .

SCIENTIFIC REPORTS, 2016, 6

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