Asgard archaea illuminate the origin of eukaryotic cellular complexity

被引：681

作者：

Zaremba-Niedzwiedzka, Katarzyna ^{[1
]}

Caceres, Eva F. ^{[1
]}

Saw, Jimmy H. ^{[1
]}

Backstrom, Disa ^{[1
]}

Juzokaite, Lina ^{[1
]}

Vancaester, Emmelien ^{[1
,9
,10
]}

Seitz, Kiley W. ^{[2
]}

Anantharaman, Karthik ^{[3
,4
]}

Starnawski, Piotr ^{[5
,6
]}

Kjeldsen, Kasper U. ^{[5
,6
]}

Stott, Matthew B. ^{[7
]}

Nunoura, Takuro ^{[8
]}

Banfield, Jillian F. ^{[3
,4
]}

Schramm, Andreas ^{[5
,6
]}

Baker, Brett J. ^{[2
]}

Spang, Anja ^{[1
]}

Ettema, Thijs J. G. ^{[1
]}

机构：

[1] Uppsala Univ, Dept Cell & Mol Biol, Sci Life Lab, SE-75123 Uppsala, Sweden

[2] Univ Texas Austin, Inst Marine Sci, Dept Marine Sci, Port Aransas, TX 78373 USA

[3] Univ Calif Berkeley, Dept Earth & Planetary Sci, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Dept Environm Sci Policy & Management, Berkeley, CA 94720 USA

[5] Aarhus Univ, Sect Microbiol, DK-8000 Aarhus, Denmark

[6] Aarhus Univ, Ctr Geomicrobiol, Dept Biosci, DK-8000 Aarhus, Denmark

[7] Extremophile Res Grp, GNS Sci, Private Bag 2000, Taupo 3352, New Zealand

[8] Japan Agcy Marine Earth Sci & Technol, Res & Dev Ctr Marine Biosci, Yokosuka, Kanagawa 2370061, Japan

[9] Univ Ghent, Dept Plant Syst Biol, VIB, Technol Pk 927, B-9052 Ghent, Belgium

[10] Univ Ghent, Dept Plant Biotechnol & Bioinformat, Technol Pk 927, B-9052 Ghent, Belgium

来源：

NATURE | 2017年 / 541卷 / 7637期

基金：

瑞典研究理事会; 欧洲研究理事会; 新加坡国家研究基金会;

关键词：

MAXIMUM-LIKELIHOOD PHYLOGENIES; MEMBRANE-TRAFFICKING SYSTEM; SINGLE-CELL; EVOLUTION; SEQUENCE; DOMAIN; LIFE; RECONSTRUCTION; MITOCHONDRIA; DATABASE;

D O I：

10.1038/nature21031

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The origin and cellular complexity of eukaryotes represent a major enigma in biology. Current data support scenarios in which an archaeal host cell and an alphaproteobacterial (mitochondrial) endosymbiont merged together, resulting in the first eukaryotic cell. The host cell is related to Lokiarchaeota, an archaeal phylum with many eukaryotic features. The emergence of the structural complexity that characterizes eukaryotic cells remains unclear. Here we describe the 'Asgard' superphylum, a group of uncultivated archaea that, as well as Lokiarchaeota, includes Thor-, Odin- and Heimdallarchaeota. Asgard archaea affiliate with eukaryotes in phylogenomic analyses, and their genomes are enriched for proteins formerly considered specific to eukaryotes. Notably, thorarchaeal genomes encode several homologues of eukaryotic membrane-trafficking machinery components, including Sec23/24 and TRAPP domains. Furthermore, we identify thorarchaeal proteins with similar features to eukaryotic coat proteins involved in vesicle biogenesis. Our results expand the known repertoire of 'eukaryote-specific' proteins in Archaea, indicating that the archaeal host cell already contained many key components that govern eukaryotic cellular complexity.

引用

页码：353 / +

页数：19

共 90 条

[81] On reduced amino acid alphabets for phylogenetic inference
Susko, Edward
Roger, Andrew J.
[J]. MOLECULAR BIOLOGY AND EVOLUTION, 2007, 24 (09) : 2139 - 2150
[82] Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
Tahirov, Tahir H.
Makarova, Kira S.
Rogozin, Igor B.
Pavlov, Youri I.
Koonin, Eugene V.
[J]. BIOLOGY DIRECT, 2009, 4
[83] Takai K, 1999, GENETICS, V152, P1285
[84] Independent Genome Reduction and Phylogenetic Reclassification of the Oceanic SAR11 Clade
Viklund, Johan
Ettema, Thijs J. G.
Andersson, Siv G. E.
[J]. MOLECULAR BIOLOGY AND EVOLUTION, 2012, 29 (02) : 599 - 615
[85] Villanueva L., 2016, ENV MICROBIOL
[86] An archaeal origin of eukaryotes supports only two primary domains of life
Williams, Tom A.
Foster, Peter G.
Cox, Cymon J.
Embley, T. Martin
[J]. NATURE, 2013, 504 (7479) : 231 - 236
[87] A congruent phylogenomic signal places eukaryotes within the Archaea
Williams, Tom A.
Foster, Peter G.
Nye, Tom M. W.
Cox, Cymon J.
Embley, T. Martin
[J]. PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2012, 279 (1749) : 4870 - 4879
[88] Phylogenomics of Prokaryotic Ribosomal Proteins
Yutin, Natalya
Puigbo, Pere
Koonin, Eugene V.
Wolf, Yuri I.
[J]. PLOS ONE, 2012, 7 (05):
[89] Archaeal origin of tubulin
Yutin, Natalya
Koonin, Eugene V.
[J]. BIOLOGY DIRECT, 2012, 7
[90] The origins of phagocytosis and eukaryogenesis
Yutin, Natalya
Wolf, Maxim Y.
Wolf, Yuri I.
Koonin, Eugene V.
[J]. BIOLOGY DIRECT, 2009, 4

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