Erasers of Histone Acetylation: The Histone Deacetylase Enzymes

被引：1482

作者：

Seto, Edward ^{[1
]}

Yoshida, Minoru ^{[2
]}

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Dept Mol Oncol, Tampa, FL 33612 USA

[2] RIKEN, Chem Genet Lab, Wako, Saitama 3510198, Japan

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2014年 / 6卷 / 04期

关键词：

SMALL-MOLECULE INHIBITOR; CLASS-I; TRANSCRIPTIONAL REPRESSION; LYSINE ACETYLATION; STRUCTURAL BASIS; ADP-RIBOSYLTRANSFERASE; ERYTHROLEUKEMIA-CELLS; NEGATIVE REGULATION; ENZYMATIC-ACTIVITY; CATALYTIC-ACTIVITY;

D O I：

10.1101/cshperspect.a018713

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl functional groups from the lysine residues of both histone and nonhistone proteins. In humans, there are 18 HDAC enzymes that use either zinc-or NAD(+)-dependent mechanisms to deacetylate acetyl lysine substrates. Although removal of histone acetyl epigenetic modification by HDACs regulates chromatin structure and transcription, deacetylation of nonhistones controls diverse cellular processes. HDAC inhibitors are already known potential anticancer agents and show promise for the treatment of many diseases.

引用

页数：26

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