Electrospun chitosan-based nanocomposite mats reinforced with chitin nanocrystals for wound dressing

被引：173

作者：

Naseri, Narges ^{[1
]}

Algan, Constance ^{[1
]}

Jacobs, Valencia ^{[2
]}

John, Maya ^{[2
]}

Oksman, Kristiina ^{[1
]}

Mathew, Aji P. ^{[1
]}

机构：

[1] Lulea Univ Technol, Dept Engn Sci & Math, Div Mat Sci, S-97187 Lulea, Sweden

[2] CS1R Mat Sci & Mfg, Fibers & Text Competence Area, ZA-6000 Port Elizabeth, South Africa

来源：

CARBOHYDRATE POLYMERS | 2014年 / 109卷

基金：

新加坡国家研究基金会; 瑞典研究理事会;

关键词：

Electrospinning; Chitin nanocrystals; Nanocomposite; Wound dressing; Mechanical properties; Cytocompatibility; THERMAL-ANALYSIS; NANOFIBROUS MEMBRANE; POLYMER NANOFIBERS; ACETIC-ACID; FABRICATION; GELATIN; SYSTEMS;

D O I：

10.1016/j.carbpol.2014.03.031

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The aim of this study was to develop electrospun chitosan/polyethylene oxide-based randomly oriented fiber mats reinforced with chitin nanocrystals (ChNC) for wound dressing. Microscopy studies showed porous mats of smooth and beadless fibers with diameters between 223 and 966 nm. The addition of chitin nanocrystals as well as crosslinking had a positive impact on the mechanical properties of the mats, and the crosslinked nanocomposite mats with a tensile strength of 64.9 MPa and modulus of 10.2 GPa were considered the best candidate for wound dressing application. The high surface area of the mats (35 m(2) g(-1)) was also considered beneficial for wound healing. The water vapor transmission rate of the prepared mats was between 1290 and 1548 g m(-2) day(-1), and was in the range for injured skin or wounds. The electrospun fiber mats showed compatibility toward adipose derived stem cells, further confirming their potential use as wound dressing materials.(c) 2014 Elsevier Ltd. All rights reserved.

引用

页码：7 / 15

页数：9

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